Selective Inhibition of p70 S6 Kinase Activation by Phosphatidylinositol 3‐Kinase Inhibitors

Oncogenes and signal transduction

1991 • 2,816 citations

[12] Determination of total protein

1983 • 1,309 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1992 • 692 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

1994 • 620 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

Wortmannin, a microbial product inhibitor of myosin light chain kinase.

1992 • 434 citations

Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.

1990 • 401 citations

The effect of serum, EGF, PGF2α and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis

1982 • 362 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.

1988 • 282 citations

Insulin-Stimulated GLUT4 Translocation Is Relevant to the Phosphorylation of IRS-1 and the Activity of PI3 Kinase

1993 • 277 citations

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

1993 • 259 citations

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1989 • 256 citations

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

1994 • 212 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

1994 • 207 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.

1991 • 182 citations

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.

1990 • 179 citations

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.

1989 • 174 citations

Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

1988 • 151 citations

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1987 • 142 citations

Inositol lipids in cell signalling

1992 • 127 citations

Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation.

1990 • 126 citations

S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment.

1988 • 118 citations

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1991 • 118 citations

A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3‐kinase

1994 • 115 citations

Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.

1991 • 113 citations

In vivo Phosphorylation and Activation of Ribosomal Protein S6 Kinases during Xenopus Oocyte Maturation

1989 • 102 citations

Phosphatidylinositol 3-kinase: a novel effector.

1992 • 99 citations

Activation of Protein Kinase C by Phosphatidylinositol 3,4,5-Trisphosphate

1993 • 76 citations

Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide.

1990 • 67 citations

Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation

1992 • 51 citations

Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors

1992 • 43 citations

[22] Purification and properties of mitogen-activated S6 kinase from rat liver and 3T3 cells

1991 • 40 citations

Biochemical characterization of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha.p85 alpha forms of the mammalian phosphatidylinositol 3-kinase.

1994 • 34 citations

Mammalian phosphatidylinositol 3′‐kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product

1994 • 22 citations