Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Multiple types of neuronal calcium channels and their selective modulation

1988 • 1,399 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Classes of Calcium Channels in Vertebrate Cells

1989 • 1,082 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Role of ion flux in the control of c-fos expression

1986 • 1,006 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription

1986 • 761 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1992 • 714 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

The pathway to signal achievement

1993 • 563 citations

Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors

1991 • 520 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons

1990 • 512 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

G protein-coupled mechanisms and nervous signaling

1992 • 474 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

1991 • 464 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes

1991 • 429 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

An enzymatic mechanism for calcium current inactivation in dialysed Helix neurones.

1986 • 409 citations

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

1992 • 363 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

1993 • 333 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor

1993 • 304 citations

Regulation of neuronal function by calcium

1989 • 302 citations

Subunit structure and localization of dihydropyridine-sensitive calcium channels in mammalian brain, spinal cord, and retina

1990 • 292 citations

A conserved kinase cascade for MAP kinase activation in yeast

1993 • 255 citations

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.

1993 • 253 citations

Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation

1988 • 250 citations

Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.

1991 • 247 citations

ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels

1990 • 244 citations

Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.

1992 • 240 citations

Dual-specificity protein kinases: will any hydroxyl do?

1992 • 235 citations

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade.

1992 • 219 citations

Nerve growth factor: a tale of two receptors.

1993 • 215 citations

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.

1992 • 202 citations

ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

1989 • 192 citations

The Many Roads That Lead to Ras

1993 • 185 citations

cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.

1993 • 179 citations

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1993 • 179 citations

Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F.

1986 • 178 citations

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.

1993 • 171 citations

p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites

1993 • 158 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

1991 • 143 citations

A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts.

1990 • 142 citations

Activation of p42 Mitogen‐Activated Protein Kinase by Glutamate Receptor Stimulation in Rat Primary Cortical Cultures

1993 • 141 citations

Erks: their fifteen minutes has arrived.

1992 • 133 citations

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

1993 • 128 citations

Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons.

1993 • 122 citations

Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation.

1993 • 121 citations

Mode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyrosine phosphatase

1993 • 116 citations

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase

1993 • 116 citations

Negative Regulation of CD45 Protein Tyrosine Phosphatase Activity by Ionomycin in T Cells

1991 • 108 citations

Increased tyrosine kinase activity of c-Src during calcium-induced keratinocyte differentiation.

1992 • 105 citations

Tyrosine Phosphorylation of Microtubule‐Associated Protein Kinase After Transient Ischemia in the Gerbil Brain

1992 • 81 citations

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

1994 • 78 citations

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

1993 • 73 citations

Identification of p42 Mitogen‐Activated Protein Kinase as a Tyrosine Kinase Substrate Activated by Maximal Electroconvulsive Shock in Hippocampus

1993 • 72 citations

Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase.

1992 • 72 citations

Nicotinic and muscarinic agonists stimulate rapid protein kinase C translocation in PC12 cells

1989 • 71 citations

Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain

1993 • 66 citations

p^44mpk MAP kinase induces aizheimer type alterations in tau function and in primary hippocampal neurons

1993 • 58 citations

MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.

1993 • 55 citations

Early Enhancement of Calcium Currents by H- ras Oncoproteins Injected into Hermissenda Neurons

1990 • 49 citations

Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase

1993 • 41 citations

Activation of p21ras by nerve growth factor in embryonic sensory neurons and PC12 cells.

1993 • 40 citations

Identification and characterization of a nerve growth factor-stimulated mitogen-activated protein kinase activator in PC12 cells.

1993 • 31 citations

Nicotinic Agonists, Phorbol Esters, and Growth Factors Activate Two Extracellular Signal‐Regulated Kinases, ERK1 and ERK2, in Bovine Chromaffin Cells

1992 • 23 citations

Deleted Work

1955 • 0 citations