Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency

Inhibition of Access of Bound Somatomedin to Membrane Receptor and Immunobinding Sites: A Comparison of Radioreceptor and Radioimmunoassay of Somatomedin in Native and Acid-Ethanol-Extracted Serum*

1980 • 752 citations

A Prospective Study of Dehydroepiandrosterone Sulfate, Mortality, and Cardiovascular Disease

1986 • 683 citations

Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.

1981 • 645 citations

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge Study to a sociobiomedical issue

2000 • 578 citations

Neurosteroids: A new brain function?

1990 • 526 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age [published erratum appears in J Clin Endocrinol Metab 1995 Sep;80(9):2799]

1994 • 454 citations

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

1998 • 444 citations

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

1990 • 433 citations

The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age‐advanced men and women

1998 • 421 citations

Dehydroepiandrosterone Reduces Serum Low Density Lipoprotein Levels and Body Fat but Does not Alter Insulin Sensitivity in Normal Men*

1988 • 420 citations

Circulating Levels of Allopregnanolone in Humans: Gender, Age, and Endocrine Influences

1998 • 371 citations

Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison’s Disease in a Randomized, Double Blind Trial

2000 • 360 citations

The Cellular and Subcellular Bases of Immunosenescence

1989 • 326 citations

Age and sex related differences in serum levels of unconjugated dehydroepiandrosterone and its sulphate in normal subjects

1997 • 320 citations

Dehydroepiandrosterone Activates Endothelial Cell Nitric-oxide Synthase by a Specific Plasma Membrane Receptor Coupled to Gαi2,3

2002 • 285 citations

Receptor binding and electrophysiological effects of Dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor

1991 • 216 citations

Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures

1999 • 212 citations

Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice

1987 • 199 citations

Dehydroepiandrosterone Modulates Endothelial Nitric Oxide Synthesis Via Direct Genomic and Nongenomic Mechanisms

2003 • 182 citations

Marked Decline in Serum Concentrations of Adrenal C19 Sex Steroid Precursors and Conjugated Androgen Metabolites During Aging

1997 • 181 citations

Relationship of prediagnostic serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing premenopausal breast cancer.

1992 • 181 citations

Neuro-steroids: 3β-hydroxy-δ5-derivatives in rat and monkey brain

1987 • 174 citations

The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men

1994 • 156 citations

Andropause

2000 • 145 citations

Biotransformation of Oral Dehydroepiandrosterone in Elderly Men: Significant Increase in Circulating Estrogens

1999 • 144 citations

Dehydroepiandrosterone Supplementation in Healthy Men with an Age-Related Decline of Dehydroepiandrosterone Secretion

2001 • 142 citations

Low Dehydroepiandrosterone and Ischemic Heart Disease in Middle-aged Men: Prospective Results from the Massachusetts Male Aging Study

2001 • 139 citations

Effect of 1-Year Oral Administration of Dehydroepiandrosterone to 60- to 80-Year-Old Individuals on Muscle Function and Cross-sectional Area

2003 • 138 citations

Conversion of Progesterone to 5α-Pregnane-3,20-dione and 3α-Hydroxy-5α-pregnan-20-one by Rat Medial Basal Hypothalami and the Effects of Estradiol and Stage of Estrous Cycle on the Conversion*

1973 • 124 citations

Protection from glucocorticoid induced thymic involution by dehydroepiandrosterone

1990 • 118 citations

The age of dehydroepiandrosterone

1995 • 114 citations

Physiological Changes in Dehydroepiandrosterone Are Not Reflected by Serum Levels of Active Androgens and Estrogens But of Their Metabolites: Intracrinology

1997 • 108 citations

Effects of age, smoking and vitamins on plasma DHEAS levels: a cross-sectional study in men.

1992 • 88 citations

Allopregnanolone and dehydroepiandrosterone response to corticotropin-releasing factor in patients suffering from Alzheimer's disease and vascular dementia

2000 • 76 citations

Relationship of body fat percentage and fat distribution with dehydroepiandrosterone sulfate in premenopausal females.

1993 • 68 citations

Proopiocortin-Related Peptide Plasma Levels throughout Prepuberty and Puberty*

1983 • 66 citations

Effect of different hormonal replacement therapies on circulating allopregnanolone and dehydroepiandrosterone levels in postmenopausal women

2003 • 65 citations

Nutritional regulation of gene expression of insulin-like growth factor-binding proteins and the acid-labile subunit in various tissues of rats

1996 • 64 citations

Oral dehydroepiandrosterone supplementation modulates spontaneous and growth hormone-releasing hormone-induced growth hormone and insulin-like growth factor-1 secretion in early and late postmenopausal women

2001 • 49 citations

Endocrine ,neuroendocrine and behavioral effects of oral dehydroepiandrosterone sulfate supplementation in postmenopausal women

1999 • 44 citations

Neuroendocrine effects of different estradiol-progestin regimens in postmenopausal women

1997 • 44 citations

Relationship between serum dehydroepiandrosterone sulfate, androstenedione, and sex hormones in men and women

1996 • 33 citations

Effect of steroid hormones and antihormones on hypothalamic beta-endorphin concentrations in intact and castrated female rats

1990 • 33 citations

Toxic adenoma and papillary thyroid carcinoma in a patient with Graves’ disease

1999 • 16 citations

Acute oral administration of dehydroepiandrosterone in male subjects: effect of age on bioavailability, sulfoconjugation and bioconversion in other steroids.

1999 • 8 citations

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