Neuropsychopharmacological properties of neuroactive steroids

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Cloning of Human Mineralocorticoid Receptor Complementary DNA: Structural and Functional Kinship with the Glucocorticoid Receptor

1987 • 1,920 citations

Primary structure and expression of a functional human glucocorticoid receptor cDNA

1985 • 1,851 citations

Neurosteroids: Endogenous bimodal modulators of the GABAA receptor mechanism of action and physiological significance

1992 • 1,098 citations

Molecular biology of GABA _A receptors

1990 • 947 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

Non-genomic and genomic effects of steroids on neural activity

1991 • 731 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

1998 • 658 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

Neurosteroids act on recombinant human GABAA receptors

1990 • 515 citations

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

1988 • 459 citations

Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor

1991 • 454 citations

Effects of Antidepressant Treatment on Neuroactive Steroids in Major Depression

1998 • 445 citations

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

1990 • 433 citations

Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABA_A Receptors

1995 • 385 citations

Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation.

1994 • 343 citations

Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.

1990 • 328 citations

Anxiolytic activity of an endogenous adrenal steroid

1986 • 317 citations

The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus

1994 • 302 citations

Progesterone receptor-mediated effects of neuroactive steroids

1993 • 297 citations

Neurosteroids: a new function in the brain

1991 • 296 citations

Synthesis, metabolism, and pharmacological activity of 3.alpha.-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes

1990 • 295 citations

Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one

1991 • 293 citations

Sleep and the sleep electroencephalogram across the menstrual cycle in young healthy women.

1996 • 288 citations

Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons

1988 • 271 citations

Anxiolytic effect of progesterone is associated with increases in cortical alloprenanolone and GABAA receptor function

1993 • 257 citations

Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy

1984 • 245 citations

Chemical Characterization of Neuroendocrine Targets for Progesterone in the Female Rat Brain and Pituitary

1990 • 235 citations

Dehydroepiandrosterone and its sulfate enhance memory retention in mice

1988 • 232 citations

Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.

1993 • 223 citations

The Chicken Progesterone Receptor A and B Isoforms Are Products of an Alternate Translation Initiation Event

1989 • 196 citations

Progesterone and the premenstrual syndrome: a double blind crossover trial.

1985 • 191 citations

Changes in Sleep and Sleep Electroencephalogram During Pregnancy

1994 • 183 citations

Circulating levels of anxiolytic steroids in the luteal phase in women with premenstrual syndrome and in control subjects.

1994 • 178 citations

Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators

1996 • 174 citations

Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats

1994 • 166 citations

Neurosteroid metabolism. 7α-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes

1992 • 165 citations

Progesterone-induced changes in sleep in male subjects

1997 • 161 citations

Anxiolytic Metabolites of Progesterone: Correlation with Mood and Performance Measures following Oral Progesterone Administration to Healthy Female Volunteers

1993 • 161 citations

Chapter 21 The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia

1992 • 160 citations

Effect of zolpidem on sleep and sleep EEG spectra in healthy young men

1991 • 151 citations

Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents

1995 • 149 citations

Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia

1991 • 148 citations

Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.

1990 • 146 citations

PROGESTERONE “ANESTHESIA” IN HUMAN SUBJECTS

1954 • 144 citations

Allopregnanolone affects sleep in a benzodiazepine-like fashion.

1997 • 143 citations

Differential localization of the 5 alpha-reductase and the 3 alpha-hydroxysteroid dehydrogenase in neuronal and glial cultures.

1993 • 143 citations

Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex

1990 • 141 citations

Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites

1988 • 137 citations

Serum dehydroepiandrosterone sulfate levels as an individual marker.

1994 • 136 citations

Stimulation of Brain Pregnenolone Synthesis by Mitochondrial Diazepam Binding Inhibitor Receptor Ligands In Vivo

1993 • 129 citations

Marked Decrease of Plasma Neuroactive Steroids During Alcohol Withdrawal

1996 • 124 citations

Initial Human Experience with Ganaxolone, a Neuroactive Steroid with Antiepileptic Activity

1997 • 122 citations

Dynamics of Slow-Wave Activity and Spindle Frequency Activity in the Human Sleep EEG: Effect of Midazolam and Zopiclone

1994 • 114 citations

Drug discrimination analysis of endogenous neuroactive steroids in rats

1993 • 114 citations

Analgesic effects of the progesterone metabolite, 3α-hydroxy-5α-pregnan-20-one, and possible modes of action in mice

1987 • 112 citations

Modulation of memory processing by glutamic acid receptor agonists and antagonists

1990 • 111 citations

Pregnanolone emulsion A preliminary pharmacokinetic and pharmacodynamic study of a new intravenous anaesthetic agent

1990 • 108 citations

DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range

1995 • 103 citations

Daily plasma estradiol and progesterone levels over the menstrual cycle and their relation to premenstrual symptoms

1995 • 96 citations

A placebo‐controlled study of effects of oral progesterone on performance and mood.

1992 • 95 citations

Dehydroepiandrosterone functions as more than an antiglucocorticoid in preserving immunocompetence after thermal injury.

1995 • 84 citations

Autoradiographic localization of glucocorticosteroid and progesterone binding sites in the human post-mortem brain

1986 • 82 citations

Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation

1993 • 80 citations

The relationship between the effects of metyrapone treatment on depressed mood and urinary steroid profiles

1996 • 67 citations

Pregnenolone enhances EEG delta activity during non-rapid eye movement sleep in the rat, in contrast to midazolam

1994 • 67 citations

Implications for theories of anaesthesia of antagonism between anaesthetic and non-anaesthetic steroids

1975 • 60 citations

5β-Pregnan-3β-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor-complex

1992 • 58 citations

Anxiolytic activity of steroid anesthetic alphaxalone.

1991 • 56 citations

Anxiolytic effects of progesterone are sexually dimorphic

1986 • 50 citations

Progesterone co-administration in patients discontinuing long-term benzodiazepine therapy: effects on withdrawal severity and taper outcome

1995 • 50 citations

Progesterone enhances inhibitory responses of cerebellar Purkinje cells mediated by the GABAA receptor subtype

1989 • 48 citations

Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers

1998 • 41 citations

Pituitary 5 alpha-dihydroprogesterone 3 alpha-hydroxysteroid oxidoreductases. Subcellular location and properties of NADH- and NADPH-linked activities.

1980 • 40 citations

Dehydroepiandrosterone regulation of the hepatic glucocorticoid receptor in the zucker rat. The obesity research program

1993 • 32 citations

The NMDA receptor antagonists, CPP and γ-l-glutamyl-l-aspartate, selectively block post-training improvement of performance in a Y-maze avoidance learning task

1991 • 27 citations

Assessment of Cognitive Performance after Progesterone Administration in Healthy Male Volunteers

1997 • 24 citations

Do neuroactive steroids cause fatigue in pregnancy?

1995 • 15 citations