A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Proliferation, cell cycle and apoptosis in cancer

2001 • 3,236 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 • 1,782 citations

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

1982 • 1,746 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

1998 • 756 citations

The ARF/p53 pathway

2000 • 647 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Translocation and Rearrangements of the c- myc Oncogene Locus in Human Undifferentiated B-Cell Lymphomas

1983 • 514 citations

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

1982 • 471 citations

Reversible Activation of c-Myc in Skin

1999 • 468 citations

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

1999 • 455 citations

The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice

1986 • 441 citations

Modeling hysteresis in piezoceramic actuators

1995 • 435 citations

Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.

1994 • 432 citations

Mechanisms of apoptosis by c-Myc

1999 • 430 citations

The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells.

1988 • 409 citations

Expression of the Epstein–Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice

1998 • 390 citations

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

1999 • 386 citations

c-Myc enhances protein synthesis and cell size during B lymphocyte development

1999 • 357 citations

Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in transgenic mice.

1996 • 332 citations

Multiple monoclonal B cell expansions and c-myc oncogene rearrangements in acquired immune deficiency syndrome-related lymphoproliferative disorders. Implications for lymphomagenesis.

1986 • 289 citations

Genetic analysis of chemoresistance in primary murine lymphomas

2000 • 276 citations

A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia.

1984 • 227 citations

Apoptosis Triggered by Myc-Induced Suppression of Bcl-X_L or Bcl-2 Is Bypassed during Lymphomagenesis

2001 • 210 citations

Burkitt Lymphoma in the Mouse

2000 • 209 citations

The status of Ig loci rearrangements in single cells from different stages of B cell development

1995 • 186 citations

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

1999 • 153 citations

Overexpression of MYC causes p53 -dependent G ₂ arrest of normal fibroblasts

2000 • 132 citations

Transgenic mice bearing the human c-myc gene activated by an immunoglobulin enhancer: a pre-B-cell lymphoma model.

1988 • 118 citations

Angiogenesis is an early event in the generation of myc-induced lymphomas

2000 • 90 citations

Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

1999 • 79 citations

An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype.

2000 • 78 citations

A mouse c-myc retrovirus transforms established fibroblast lines in vitro and induces monocyte-macrophage tumors in vivo

1986 • 65 citations

Functional analysis of the AUG- and CUG-initiated forms of the c-Myc protein.

1994 • 45 citations

Acquired immunodeficiency syndrome‐related systemic non‐Hodgkin's lymphoma

2001 • 29 citations

Multistep evolution of B-cell-derived tumors in humans and rodents

1993 • 16 citations

EBNA2 and c-myc in B Cell Immortalization by Epstein-Barr Virus and in the Pathogenesis of Burkitt’s Lymphoma

1999 • 11 citations

Intratumoral delivery of an interferon gamma retrovirus-producing cells inhibits growth of a murine melanoma by a non-immune mechanism

2001 • 8 citations