Mechanisms of Transcriptional Repression by Myc

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

2002 • 1,984 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

2004 • 784 citations

Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

2002 • 676 citations

Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression

2002 • 624 citations

GADD45 induction of a G ₂ /M cell cycle checkpoint

1999 • 607 citations

Repression of p15INK4b expression by Myc through association with Miz-1

2001 • 571 citations

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

2001 • 540 citations

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

2002 • 502 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

Myc represses transcription through recruitment of DNA methyltransferase corepressor

2004 • 425 citations

Myc represses the p21 ^(WAF1/CIP1) promoter and interacts with Sp1/Sp3

2001 • 411 citations

An alternative pathway for gene regulation by Myc

1997 • 365 citations

p53-independent functions of the p19^ARF tumor suppressor

2000 • 356 citations

RETRACTED: Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

2003 • 323 citations

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

1999 • 319 citations

Deregulated expression of c-Myc depletes epidermal stem cells

2001 • 316 citations

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II.

1994 • 313 citations

Negative Regulation of the Mammalian UV Response by Myc through Association with Miz-1

2002 • 306 citations

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

2003 • 303 citations

Reciprocal Regulation of Adipogenesis by Myc and C/EBPα

1992 • 296 citations

Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II

1995 • 290 citations

E2F1 and c-Myc Potentiate Apoptosis through Inhibition of NF-κB Activity that Facilitates MnSOD-Mediated ROS Elimination

2002 • 282 citations

Inhibition of Transcriptional Regulator Yin-Yang-1 by Association with c-Myc

1993 • 273 citations

Repression of transcription of the p27Kip1 cyclin-dependent kinase inhibitor gene by c-Myc

2001 • 267 citations

Epigenetic lesions causing genetic lesions in human cancer

2000 • 256 citations

A role for transcriptional repression of p21 ^CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

2000 • 249 citations

Direct role for Myc in transcription initiation mediated by interactions with TFII-I

1993 • 246 citations

p21/CDKN1A Mediates Negative Regulation of Transcription by p53

2003 • 229 citations

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

2003 • 224 citations

Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15^Ink4b G₁ Arrest Pathway

1999 • 224 citations

Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15Ink4B

2002 • 224 citations

p19ARF directly and differentially controls the functions of c-Myc independently of p53

2004 • 216 citations

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

2003 • 185 citations

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

2003 • 182 citations

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2 and c-Myc expression

2001 • 172 citations

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma

2002 • 138 citations

Down-regulation of LFA-1 Adhesion Receptors by C-mycOncogene in Human B Lymphoblastoid Cells

1990 • 136 citations

The p400 E1A-associated protein is a novel component of the p53 → p21 senescence pathway

2005 • 133 citations

c-Myc Overexpression Uncouples DNA Replication from Mitosis

1999 • 128 citations

Myc-ARF (Alternate Reading Frame) Interaction Inhibits the Functions of Myc

2004 • 112 citations

Mechanism for the transcriptional repression by c-Myc on PDGF β-receptor

2001 • 101 citations

Viral Myc Oncoproteins in Infected Fibroblasts Down-modulate Thrombospondin-1, a Possible Tumor Suppressor Gene

1996 • 92 citations

Myc represses transcription of the growth arrest gene gas1

1997 • 88 citations

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

1998 • 85 citations

Functional analysis of the N-terminal domain of the Myc oncoprotein

2003 • 84 citations

Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1

2004 • 81 citations

A link between c-Myc-mediated transcriptional repression and neoplastic transformation.

1996 • 68 citations

Overexpression of Myc suppresses CCAAT transcription factor/nuclear factor 1-dependent promoters in vivo.

1993 • 64 citations

CIF150, a Human Cofactor for Transcription Factor IID-Dependent Initiator Function

1998 • 63 citations

Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc

2003 • 56 citations

Transformation by myc prevents fusion but not biochemical differentiation of C2C12 myoblasts: mechanisms of phenotypic correction in mixed culture with normal cells.

1994 • 52 citations