Activation of Transferrin Receptor 1 by c-Myc Enhances Cellular Proliferation and Tumorigenesis

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform

2004 • 3,585 citations

c-Myc-regulated microRNAs modulate E2F1 expression

2005 • 2,371 citations

Identifying biological themes within lists of genes with EASE

2003 • 1,969 citations

A Detergent‐trypsin method for the preparation of nuclei for flow cytometric DNA analysis

1983 • 1,681 citations

c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism

1999 • 1,650 citations

Large-scale analysis of the human and mouse transcriptomes

2002 • 1,493 citations

c-MYC: more than just a matter of life and death

2002 • 1,147 citations

Transcriptional regulation and transformation by Myc proteins

2005 • 1,102 citations

Genomic targets of the human c-Myc protein

2003 • 956 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

2003 • 787 citations

Cellular Senescence

2000 • 743 citations

Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

2005 • 579 citations

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1996 • 544 citations

Transferrin receptors in human tissues: their distribution and possible clinical relevance.

1983 • 527 citations

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

2003 • 524 citations

Structure of the Human Transferrin Receptor-Transferrin Complex

2004 • 507 citations

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

2003 • 481 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

The myc Oncogene: omplex

2002 • 458 citations

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

1987 • 457 citations

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

1997 • 447 citations

Genomic binding by theDrosophilaMyc, Max, Mad/Mnt transcription factor network

2003 • 392 citations

Modulation of cell surface iron transferrin receptors by cellular density and state of activation

1979 • 366 citations

c-Myc enhances protein synthesis and cell size during B lymphocyte development

1999 • 357 citations

Coordinated Regulation of Iron-Controlling Genes, H-Ferritin and IRP2 , by c-MYC

1999 • 319 citations

The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation

1999 • 316 citations

The transcriptional program of a human B cell line in response to Myc

2001 • 312 citations

Myc target genes

1997 • 289 citations

c-Myc target gene specificity is determined by a post-DNAbinding mechanism

1998 • 280 citations

Transformation of follicular lymphoma to diffuse large-cell lymphoma: Alternative patterns with increased or decreased expression of c - myc and its regulated genes

2002 • 225 citations

A Large Scale Genetic Analysis of c-Myc-regulated Gene Expression Patterns

2003 • 224 citations

Iron chelators as therapeutic agents for the treatment of cancer

2002 • 222 citations

Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo.

1996 • 210 citations

Cell cycle activation by c-myc in a Burkitt lymphoma model cell line

2000 • 203 citations

A Functional Screen for Myc-Responsive Genes Reveals Serine Hydroxymethyltransferase, a Major Source of the One-Carbon Unit for Cell Metabolism

2002 • 194 citations

The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation

2002 • 193 citations

Antineuroblastoma activity of desferoxamine in human cell lines.

1987 • 146 citations

Effects of c-myc Expression on Cell Cycle Progression

1994 • 141 citations

Regulation of transferrin receptor expression on human leukemic cells during proliferation and induction of differentiation. Effects of gallium and dimethylsulfoxide.

1983 • 130 citations

Characterization of Nucleophosmin (B23) as a Myc Target by Scanning Chromatin Immunoprecipitation

2001 • 124 citations

Neoplastic transformation by the human gene N-myc.

1987 • 124 citations

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

2004 • 119 citations

A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients

2003 • 112 citations

Myc

2004 • 109 citations

Deferoxamine inhibition of human neuroblastoma viability and proliferation.

1988 • 108 citations

Definition of Regions in Human c-myc that are Involved in Transformation and Nuclear Localization

1987 • 106 citations

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites

2003 • 105 citations

Functional analysis of the N-terminal domain of the Myc oncoprotein

2003 • 84 citations

Effects of anti‐transferrin receptor antibodies on growth of normal and malignant myeloid cells

1983 • 82 citations

The mechanism of 67Ga localization in malignant disease

1996 • 80 citations

Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells.

2001 • 62 citations

Transferrin Receptor Expression and the Control of Cell Growth

1986 • 60 citations

Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway

2003 • 60 citations

Targeting c-Myc-activated genes with a correlation method: Detection of global changes in large gene expression network dynamics

2005 • 54 citations

A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis

2002 • 52 citations

Therapeutic Potential of Iron Chelators in Cancer Therapy

2002 • 40 citations

Inactivation of Myc in Murine Two-Hit B lymphomas Causes Dormancy with Elevated Levels of Interleukin 10 Receptor and CD20: Implications for Adjuvant Therapies

2005 • 31 citations

The transferrin receptor: a key function in iron metabolism.

1989 • 21 citations

CD71 phenotype and the value of gallium imaging in lymphomas

1991 • 19 citations

Effects of Anti-Transferrin Receptor Antibodies on the Growth of Neoplastic Cells

1992 • 16 citations

Characterization of the Murine Nramp1 Promoter

2003 • 12 citations

c-Myc represses the murine Nrampl promoter

2002 • 12 citations