c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

Shared Principles in NF-κB Signaling

2008 • 4,283 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Introduction to NF-κB: players, pathways, perspectives

2006 • 2,115 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Regulatory T Cells in Autoimmmunity

2000 • 1,267 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

FOXP3: Of Mice and Men

2005 • 929 citations

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3

2007 • 819 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

Foxp3 in control of the regulatory T cell lineage

2007 • 690 citations

Journey through the thymus: stromal guides for T-cell development and selection

2006 • 690 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

IκB kinase complexes: gateways to NF-κB activation and transcription

2006 • 628 citations

A Two-Step Process for Thymic Regulatory T Cell Development

2008 • 615 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Selective Events in T Cell Development

1994 • 486 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

2002 • 465 citations

Developmental regulation of Foxp3 expression during ontogeny

2005 • 418 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival

1999 • 354 citations

Dendritic cells in the thymus contribute to T-regulatory cell induction

2008 • 292 citations

The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology

2006 • 289 citations

Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

2006 • 288 citations

Control of lymphocyte development by nuclear factor-κB

2005 • 271 citations

Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period

2005 • 237 citations

Regulatory T cells in autoimmunity

2007 • 228 citations

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

2000 • 226 citations

Mature T Cells Depend on Signaling through the IKK Complex

2003 • 210 citations

An Essential Role for Nuclear Factor κB in Promoting Double Positive Thymocyte Apoptosis

1999 • 207 citations

Thymic development and peripheral homeostasis of regulatory T cells

2007 • 160 citations

The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects

1999 • 144 citations

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

2002 • 143 citations

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

2006 • 142 citations

Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 • 127 citations

Regulatory T Cells Suppress CD8+ T Cell Responses Induced by Direct Priming and Cross-Priming and Moderate Immunodominance Disparities

2005 • 126 citations

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

2003 • 120 citations

Defining the Ability of Cyclophosphamide Preconditioning to Enhance the Antigen-specific CD8+ T-cell Response to Peptide Vaccination: Creation of a Beneficial Host Microenvironment Involving Type I IFNs and Myeloid Cells

2006 • 115 citations

The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling

2004 • 113 citations

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

2002 • 110 citations

The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-κB-Dependent c-myc Expression

2004 • 109 citations

Genome-Wide Analysis of Gene Expression in T Cells to Identify Targets of the NF-κB Transcription Factor c-Rel

2007 • 106 citations

CARMA1 Controls an Early Checkpoint in the Thymic Development of FoxP3+ Regulatory T Cells

2009 • 104 citations

Commitment to the Regulatory T Cell Lineage Requires CARMA1 in the Thymus but Not in the Periphery

2009 • 98 citations

The subunit composition of NF-kappa B complexes changes during B-cell development.

1994 • 93 citations

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells.

1995 • 93 citations

The Transcription Factors c-rel and RelA Control Epidermal Development and Homeostasis in Embryonic and Adult Skin via Distinct Mechanisms

2004 • 81 citations

Distinct roles for the NF-κB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals

2005 • 81 citations

The role of Rel/NF-κB transcription factors in B lymphocyte survival

2003 • 59 citations

Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

1999 • 55 citations

CD4⁺ CD25⁺ Regulatory T Cell Selection

2004 • 40 citations

Temporal and Subunit-specific Modulations of the Rel/NF-κB Transcription Factors Through CD28 Costimulation

1997 • 37 citations

Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells

2006 • 19 citations

The Cross-Priming APC Requires a Rel-Dependent Signal to Induce CTL

2002 • 15 citations