Genome-Wide Analysis of Gene Expression in T Cells to Identify Targets of the NF-κB Transcription Factor c-Rel

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Shaping the nuclear action of NF-κB

2004 • 1,183 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

1998 • 578 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

One Nucleotide in a κB Site Can Determine Cofactor Specificity for NF-κB Dimers

2004 • 383 citations

Genetic analysis of NF- B/Rel transcription factors defines functional specificities

2003 • 326 citations

Distribution of NF-κB-binding sites across human chromosome 22

2003 • 302 citations

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

2000 • 301 citations

Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

2006 • 288 citations

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

1992 • 286 citations

Highly specific localization of promoter regions in large genomic sequences by PromoterInspector: a novel context analysis approach

2000 • 286 citations

Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a Activity

2002 • 268 citations

Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells

2001 • 263 citations

Identification of Direct Genomic Targets Downstream of the Nuclear Factor-κB Transcription Factor Mediating Tumor Necrosis Factor Signaling

2005 • 230 citations

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

1997 • 224 citations

Rel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes

2000 • 193 citations

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

2002 • 193 citations

Identifying transcription factor functions and targets by phenotypic activation

2006 • 185 citations

Identification of NF-κB-regulated genes induced by TNFα utilizing expression profiling and RNA interference

2003 • 174 citations

Coordinated binding of NF-κB family members in the response of human cells to lipopolysaccharide

2006 • 174 citations

Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation

2002 • 168 citations

Expression-based monitoring of transcription factor activity: the TELiS database

2004 • 168 citations

Nucleosome remodeling at the IL-12 p40 promoter is a TLR-dependent, Rel-independent event

2001 • 164 citations

Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter

2000 • 164 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

2004 • 142 citations

Adenovirus Vector-Induced Expression of the C-X-C Chemokine IP-10 Is Mediated through Capsid-Dependent Activation of NF-κB

2000 • 137 citations

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation

2005 • 121 citations

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

2003 • 120 citations

Mouse Mammary Tumor Virus c-rel Transgenic Mice Develop Mammary Tumors

2003 • 119 citations

Chemokine and chemokine receptor gene expression indicates acute rejection of human cardiac transplants1

2003 • 110 citations

High Mobility Group Protein I(Y) Is Required for Function and for c-Rel Binding to CD28 Response Elements within the GM-CSF and IL-2 Promoters

1996 • 109 citations

The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-κB-Dependent c-myc Expression

2004 • 109 citations

Cutting Edge: Identification of c-Rel-Dependent and -Independent Pathways of IL-12 Production During Infectious and Inflammatory Stimuli

2002 • 105 citations

Differential Transcriptional Activation in Vitro by NF- κB/Rel Proteins

1995 • 101 citations

Histone Dynamics on the Interleukin-2 Gene in Response to T-Cell Activation

2005 • 95 citations

X-Ray Crystal Structure of Proto-Oncogene Product c-Rel Bound to the CD28 Response Element of IL-2

2001 • 91 citations

Predicting genetic regulatory response using classification

2004 • 90 citations

NF-κB-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1

2003 • 87 citations

Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo

2005 • 83 citations

Involvement of Jun and Rel Proteins in Up-regulation of Interleukin-4 Gene Activity by the T Cell Accessory Molecule CD28

1998 • 82 citations

Distinctions between c‐Rel and other NF‐κB proteins in immunity and disease

2003 • 79 citations

Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor κB Proteins

2003 • 71 citations

Multiple Transcription Factor Profiling by Enzyme-Linked Immunoassay

2002 • 69 citations

c-Rel regulation of the cell cycle in primary mouse B lymphocytes

2002 • 66 citations

Inhibition of NF-κB-Dependent T Cell Activation Abrogates Acute Allograft Rejection

2001 • 64 citations

Generation of an Improved Luciferase Reporter Gene Plasmid That Employs a Novel Mechanism for High-Copy Replication

2000 • 60 citations

Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

1999 • 55 citations

Identification of an NF-κB-Dependent Gene Network in Cells Infected by Mammalian Reovirus

2006 • 53 citations

Genome-wide prediction and analysis of function-specific transcription factor binding sites.

2004 • 52 citations

Tuning up inflammation: How DNA sequence and chromatin organization control the induction of inflammatory genes by NF‐κB

2006 • 52 citations

Computationally Identifying Novel NF-κB-Regulated Immune Genes in the Human Genome

2003 • 51 citations

NF-κB/Rel Family Members Regulating the ICAM-1 Promoter in Monocytic THP-1 Cells

1997 • 50 citations

Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes

2003 • 39 citations

GM-CSF promoter chromatin remodelling and gene transcription display distinct signal and transcription factor requirements

2005 • 37 citations

Enforced c-REL deficiency prolongs survival of islet allografts1

2002 • 33 citations

Assays for Transcriptional Activity Based on the Luciferase Reporter Gene

2003 • 28 citations

Molecular profiling of the role of the NF-kappaB family of transcription factors during alloimmunity.

2002 • 23 citations

Molecular profiling of the role of the NF-κB family of transcription factors during alloimmunity

2002 • 22 citations

Microarrays and Transcription Networks

2006 • 3 citations

Deciphering Regulatory Networks Controlled by the NF-kB Transcription Factor c-Rel in T Cells

2006 • 1 citations