The Transcription Factors c-rel and RelA Control Epidermal Development and Homeostasis in Embryonic and Adult Skin via Distinct Mechanisms

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

1993 • 1,102 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

1999 • 991 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

Size Control in Animal Development

1999 • 742 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

X–linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein

1996 • 739 citations

Genomic rearrangement in NEMO impairs NF-κB activation and is a cause of incontinentia pigmenti

2000 • 714 citations

NEW EMBO MEMBER'S REVIEW: Role of integrins in regulating epidermal adhesion, growth and differentiation

2002 • 616 citations

Limb and Skin Abnormalities in Mice Lacking IKKα

1999 • 609 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

2000 • 523 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1999 • 475 citations

Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice

2000 • 469 citations

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

2002 • 465 citations

Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype

1998 • 465 citations

Epithelial barrier function: assembly and structural features of the cornified cell envelope

2002 • 450 citations

Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB

1998 • 435 citations

NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti

2000 • 435 citations

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1999 • 410 citations

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

2000 • 395 citations

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia

1999 • 393 citations

Involvement of a novel Tnf receptor homologue in hair follicle induction

1999 • 385 citations

Patterned acquisition of skin barrier function during development

1998 • 384 citations

NEW EMBO MEMBER'S REVIEW: NF-kappaB and virus infection: who controls whom

2003 • 373 citations

IKKα controls formation of the epidermis independently of NF-κB

2001 • 357 citations

Enrichment for murine keratinocyte stem cells based on cell surface phenotype

2000 • 356 citations

IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice

1996 • 347 citations

IκB proteins: structure, function and regulation

1997 • 330 citations

Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts

1999 • 322 citations

The Tabby phenotype is caused by mutation in a mouse homologue of theEDAgene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

1997 • 305 citations

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

1999 • 303 citations

Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors

2000 • 303 citations

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling.

1999 • 279 citations

Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-κB in Leukocyte Recruitment

2001 • 260 citations

Stem cell fate and patterning in mammalian epidermis

2001 • 250 citations

The epidermis: rising to the surface

1994 • 245 citations

Tumor necrosis factor: a master-regulator of leukocyte movement

2000 • 242 citations

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar

2002 • 239 citations

Requirement of NF-κB/Rel for the development of hair follicles and other epidermal appendices

2001 • 214 citations

Identification of a New Splice Form of the EDA1 Gene Permits Detection of Nearly All X-Linked Hypohidrotic Ectodermal Dysplasia Mutations

1998 • 208 citations

Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development

2000 • 151 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

2002 • 143 citations

Prevention of Hepatic Apoptosis and Embryonic Lethality in RelA/TNFR-1 Double Knockout Mice

2000 • 132 citations

It's Got You Covered

2000 • 119 citations

The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

2002 • 110 citations

Rel/NF‐κB transcription factors: key mediators of B‐cell activation

2000 • 103 citations

Mice lacking the transcription factor RelB develop T cell-dependent skin lesions similar to human atopic dermatitis

2000 • 103 citations

Prenatal formation of hair follicle types,

1962 • 84 citations

NF-κB signaling and human disease

2001 • 75 citations

Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I

2001 • 72 citations

Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes

2000 • 57 citations

NF-κB1 Can Inhibit v-Abl-Induced Lymphoid Transformation by Functioning as a Negative Regulator of Cyclin D1 Expression

2002 • 21 citations