Cell‐based vaccines for the stimulation of immunity to metastatic cancers

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

The Staphylococcal Enterotoxins and Their Relatives

1990 • 1,914 citations

SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1965 • 1,851 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING

1998 • 1,017 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.

1996 • 849 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

The role of CD4+ T cell responses in antitumor immunity

1998 • 678 citations

The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses

1998 • 666 citations

T cell defined tumor antigens

1997 • 641 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Tumor immunogenicity determines the effect of B7 costimulation on T cell-mediated tumor immunity.

1994 • 482 citations

Tumor-Specific Idiotype Vaccines in the Treatment of Patients With B-Cell Lymphoma — Long-Term Results of a Clinical Trial

1997 • 464 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines.

1998 • 388 citations

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.

1996 • 386 citations

Invariant Chain Structure and MHC Class II Function

1996 • 374 citations

Mechanisms of antigen uptake for presentation

1996 • 354 citations

Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells.

1995 • 324 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma

1997 • 319 citations

A comparison of gene transfer methods in human dendritic cells.

1997 • 315 citations

Cancer Tumor antigens

1997 • 289 citations

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge

1996 • 287 citations

Signalling through the MHC class II cytoplasmic domain is required for antigen presentation and induces B7 expression

1992 • 285 citations

Constitutive expression of B7 restores immunogenicity of tumor cells expressing truncated major histocompatibility complex class II molecules.

1993 • 274 citations

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

1995 • 267 citations

Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor: heterogeneity in phenotypic stability.

1983 • 257 citations

Minor H Antigens Introduced on H-2 Different Stimulating Cells Cross-React at the Cytotoxic T Cell Level during in Vivo Priming

1976 • 253 citations

Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA–liposome complexes

1996 • 237 citations

Human tumor antigens recognized by T cells

1996 • 217 citations

Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts

1997 • 209 citations

Mass spectrometric identification of a naturally processed melanoma peptide recognized by CD8+ cytotoxic T lymphocytes.

1995 • 208 citations

HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules

1996 • 206 citations

HLA-DM Acts as a Molecular Chaperone and Rescues Empty HLA-DR Molecules at Lysosomal pH

1997 • 199 citations

Major histocompatibility complex class II+B7-1+ tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice.

1995 • 190 citations

Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, oncogenic self-protein.

1996 • 185 citations

Immunity to Oncogenic Proteins

1995 • 180 citations

Rejection of mouse sarcoma cells after transfection of MHC class II genes.

1990 • 171 citations

Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes.

1995 • 161 citations

Oncogenic proteins as tumor antigens

1996 • 157 citations

Tumor antigens recognized by T lymphocytes

1997 • 153 citations

Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

1996 • 147 citations

Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

1994 • 135 citations

Tumor immunotherapy: the tumor cell as an antigen-presenting cell

1994 • 132 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.

1996 • 121 citations

Processing and Presentation of Endocytically Acquired Protein Antigens by MHC Class II and Class I Molecules

1996 • 99 citations

Human papillomarivus vaccines for cervical cancer

1996 • 98 citations

Peptide-based cancer vaccines

1996 • 97 citations

Requirement for recognition of class II molecules and processed tumor antigen for optimal generation of syngeneic tumor-specific class I-restricted CTL.

1986 • 97 citations

The Endogenous Pathway of MHC Class II Antigen Presentation

1996 • 91 citations

Influence of gene-modified (IL-7, IL-4, and B7) tumor cell vaccines on tumor antigen presentation.

1997 • 85 citations

MHC Class II-Transfected Tumor Cells Directly Present Antigen to Tumor-Specific CD4+ T Lymphocytes1

1998 • 81 citations

Rejection of MHC class II-transfected tumor cells requires induction of tumor-encoded B7-1 and/or B7-2 costimulatory molecules.

1996 • 73 citations

The new vaccines: building viruses that elicit antitumor immunity

1996 • 72 citations

Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells.

1996 • 67 citations

Invariant chain alters the malignant phenotype of MHC class II+ tumor cells.

1992 • 61 citations

Tumor antigen presentation: changing the rules

1998 • 52 citations

Appreciating the Complexity of MHC Class II Peptide Binding: Lysozyme Peptide and I‐A^k

1996 • 46 citations

The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16.

1991 • 46 citations

Rejection of K1735 murine melanoma in syngeneic hosts requires expression of MHC class I antigens and either class II antigens or IL-2.

1993 • 42 citations

Abrogation of tumorigenicity by MHC class II antigen expression requires the cytoplasmic domain of the class II molecule.

1991 • 37 citations

Class II-Transfected Tumor Cells Directly Present Endogenous Antigen to CD4+ T Cells In Vitro and Are APCs for Tumor-Encoded Antigens In Vivo

1998 • 34 citations

Maturation of cytotoxic T lymphocytes against a B7-transfected nonmetastatic tumor: a critical role for costimulation by B7 on both tumor and host antigen-presenting cells.

1998 • 29 citations

Single amino acid mutations in the murine MHC class II A beta cytoplasmic domain abrogate antigen presentation.

1997 • 8 citations