Oncogenic proteins as tumor antigens

Humanization of an anti-p185HER2 antibody for human cancer therapy.

1992 • 1,867 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Identification of an immunodominant peptide of HER-2/neu protooncogene recognized by ovarian tumor-specific cytotoxic T lymphocyte lines.

1995 • 542 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin.

1995 • 391 citations

Targeting p53 as a general tumor antigen.

1995 • 315 citations

Serum p53 antibodies as early markers of lung cancer

1995 • 301 citations

Specific human cellular immunity to bcr-abl oncogene-derived peptides

1996 • 300 citations

Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation.

1992 • 299 citations

The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot.

1992 • 283 citations

Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma.

1995 • 218 citations

Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation

1995 • 213 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules

1995 • 193 citations

Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, oncogenic self-protein.

1996 • 185 citations

T-cell immunity to the joining region of p210BCR-ABL protein.

1992 • 184 citations

Immunity to Oncogenic Proteins

1995 • 180 citations

Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood.

1995 • 175 citations

A mutant p53 tumor suppressor protein is a target for peptide-induced CD8+ cytotoxic T-cells.

1993 • 171 citations

Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides

1995 • 162 citations

Antibodies against p53 are associated with poor prognosis of colorectal cancer

1995 • 142 citations

Phase I trial of 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and Fc gamma RIII.

1995 • 138 citations

The epidermal growth factor receptor as a target for therapy in breast carcinoma

1994 • 134 citations

Prevention of breast tumour development in vivo by downregulation of the p185neureceptor

1995 • 114 citations

Ex vivo ras peptide vaccination in patients with advanced pancreatic cancer: Results of a phase I/II study

1996 • 112 citations

Recognition of peptides corresponding to the joining region of p210BCR-ABL protein by human T cells.

1995 • 106 citations

Primary proliferative T cell response to wild‐type p53 protein in patients with breast cancer

1995 • 98 citations

p53, a potential target for tumor-directed T cells

1994 • 88 citations

Mutant ras epitopes as targets for cancer vaccines.

1996 • 87 citations

p21‐ras‐peptide‐specific T‐cell responses in a patient with colorectal cancer. CD4⁺ and CD8⁺ T cells recognize a peptide corresponding to a common mutation (13Gly → Asp)

1994 • 85 citations

Induction and characterization of cytotoxic T‐lymphocytes recognizing a mutated p21ras peptide presented by HLA‐A*0201

1995 • 84 citations

T cell immunity to the joining region of p210^ protein.

1992 • 67 citations

CD4+ T-cell immunity to mutated ras protein in pancreatic and colon cancer patients.

1995 • 63 citations

CD8+T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (GLY13?ASP), are cytotoxic towards a carcinoma cell line harbouring the same mutation

1995 • 60 citations

Induction of T-Cell Immunity Against Ras Oncoproteins by Soluble Protein or Ras-Expressing Escherichia coli

1995 • 43 citations

Peptide‐specific activation of cytolytic CD4⁺ T lymphocytes against tumor cells bearing mutated epitopes of K‐ras p21

1995 • 42 citations

A K‐ras 13GLY → ASP mutation is recognized by HLA‐DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?

1994 • 38 citations

Serum p53 auto-antibodies: Incidence in familial breast cancer

1994 • 36 citations

Shared T Cell Epitopes in Epithelial Tumors

1995 • 36 citations

T Cell-Mediated Cytotoxicity Against p53-Protein Derived Peptides in Bulk and Limiting Dilution Cultures of Healthy Donors

1995 • 31 citations

Active Immunization Against LHRH Alone or Combined With LHRH‐Analogue Treatment Impedes Growth of Androgen‐Dependent Prostatic Carcinoma

1995 • 8 citations