Denitrosation of 1,3-bis(2-chloroethyl)-1-nitrosourea by class mu glutathione transferases and its role in cellular resistance in rat brain tumor cells.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea.

1973 • 255 citations

Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.

1988 • 208 citations

Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.

1985 • 165 citations

Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.

1987 • 155 citations

Purification of major basic glutathione transferase isoenzymes from rat liver by use of affinity chromatography and fast protein liquid chromatofocusing

1985 • 127 citations

Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.

1987 • 113 citations

A proposed mechanism of resistance to cyclophosphamide and phosphoramide mustard in a Yoshida cell line in vitro

1986 • 104 citations

Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.

1987 • 94 citations

1,3-bis (2-chloroethyl)-1-nitrosourea (NSC-409962) in the treatment of brain tumors.

1970 • 91 citations

Selective expression of a unique glutathione S-transferase Yb3 gene in rat brain.

1987 • 90 citations

Microsomal metabolism of nitrosoureas.

1975 • 86 citations

BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea; NSC-409962) in the treatment of malignant brain tumor--a preliminary report.

1970 • 77 citations

Isoenzymes of glutathione transferase in rat kidney cytosol

1985 • 55 citations

Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas.

1985 • 49 citations

Reduced level of DNA cross-links and sister chromatid exchanges in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant rat brain tumor cells.

1984 • 48 citations

Investigation of resistance to DNA cross-linking agents in 9L cell lines with different sensitivities to chloroethylnitrosoureas.

1985 • 38 citations

Tumor Cell Resistance

2015 • 25 citations

Glutathione-dependent denitrosation of N,N'-bis(2-chloroethyl)N-nitrosourea (BCNU): nitrite release catalyzed by mouse liver cytosol in vitro.

1983 • 23 citations