Cytochrome P450?inducing antiepileptics increase the clearance of vincristine in patients with brain tumors

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions.

1995 • 334 citations

Clinically Significant Pharmacokinetic Drug Interactions with Carbamazepine

1996 • 327 citations

Effect of corticosteroids on the expression of cytochromes P450 and on cyclosporin A oxidase activity in primary cultures of human hepatocytes.

1992 • 197 citations

Involvement of human liver cytochrome P450 3A in vinblastine metabolism: drug interactions.

1993 • 157 citations

Influence of prophylactic anticonvulsant therapy on high-dose busulphan kinetics

1993 • 133 citations

Pharmacokinetic Drug Interactions with Phenytoin (Part I)1

1990 • 111 citations

Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL

1995 • 103 citations

Pharmacokinetic Drug Interactions of Vinca Alkaloids: Summary of Case Reports

1998 • 97 citations

Biliary excretion of vincristine

1978 • 83 citations

Increased teniposide clearance with concomitant anticonvulsant therapy.

1992 • 80 citations

Human liver microsomal cytochrome P450 3A isozymes mediated vindesine biotransformation

1993 • 80 citations

Influence of Single and Repeated Doses of Oxcarbazepine on the Pharmacokinetic Profile of Felodipine

1993 • 68 citations

Pharmacokinetics of vincristine in cancer patients treated with nifedipine

1989 • 54 citations

Determination of vinca alkaloids in human plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

1997 • 30 citations

Dexamethasone induction of cytochrome P450 3A4 activity in human hepatocytes and healthy volunteers

1999 • 2 citations