Cellular resistance to chloroethylnitrosoureas, nitrogen mustard, and cis-diamminedichloroplatinum(II) in human glial-derived cell lines.

New Giemsa method for the differential staining of sister chromatids

1974 • 3,198 citations

Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

1980 • 371 citations

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

1980 • 315 citations

Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas.

1981 • 281 citations

Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion.

1984 • 235 citations

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1982 • 227 citations

Purification and properties of O6-methylguanine-DNA transmethylase from rat liver.

1983 • 187 citations

Heterogeneous chemosensitivities of subpopulations of human glioma cells in culture.

1982 • 170 citations

DNA-protein cross-linking and DNA interstrand cross-linking by haloethylnitrosoureas in L1210 cells.

1978 • 169 citations

Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.

1985 • 165 citations

Dechlorination of l-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content

1983 • 154 citations

Alkylating agent resistance: in vitro studies with human cell lines.

1985 • 137 citations

A system in mouse liver for the repair of O⁶-methylguanine lesions in methylated DNA

1981 • 137 citations

Patterns of Resistance and Therapeutic Synergism among Alkylating Agents1

2015 • 133 citations

Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

1984 • 127 citations

Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts.

1970 • 102 citations

Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.

1984 • 97 citations

Glutathione and related enzymes in rat brain tumor cell resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea and nitrogen mustard.

1987 • 94 citations

1,3-bis (2-chloroethyl)-1-nitrosourea (NSC-409962) in the treatment of brain tumors.

1970 • 91 citations

Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.

1984 • 88 citations

Covalent Modification of DNA by Antineoplastic Agents<xref ref-type="fn" rid="FN5">5</xref>

1984 • 88 citations

Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone

1983 • 79 citations

BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea; NSC-409962) in the treatment of malignant brain tumor--a preliminary report.

1970 • 77 citations

Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts

1984 • 75 citations

Prediction of human tumor cell chemosensitivity using the sister chromatid exchange assay.

1986 • 67 citations

Tumor subpopulation interactions in neoplasms

1983 • 56 citations

Increased repair of O⁶-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1, 3-bis(2-chloroethyl)-1-nitrosourea

1986 • 55 citations

Differential cytotoxicity and DNA cross-linking in normal and transformed human fibroblasts treated with cis-diamminedichloroplatinum(II).

1981 • 50 citations

Repair of O6-(2-chloroethyl)guanine mediates the biological effects of chloroethylnitrosoureas.

1985 • 49 citations

Reduced level of DNA cross-links and sister chromatid exchanges in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant rat brain tumor cells.

1984 • 48 citations

Nitrosourea-induced sister chromatid exchanges and correlation to cell survival in 9L rat brain tumor cells.

1983 • 47 citations

Mutagenicity and cytotoxicity of various nitrosoureas in V-79 Chinese hamster cells.

1980 • 43 citations

Nitrosourea chemotherapy for primary malignant gliomas.

1976 • 41 citations

Investigation of resistance to DNA cross-linking agents in 9L cell lines with different sensitivities to chloroethylnitrosoureas.

1985 • 38 citations

Mode of action of methylating carcinogens: comparative studies of murine and human cells

1981 • 37 citations

Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents

1985 • 34 citations

Potentiation of 1,3-BIS(2-chloroethyl)-1-nitrosourea (BCNU)-induced cytotoxicity in 9L cells by pretreatment with 6-thioguanine

1985 • 27 citations

Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards.

1982 • 23 citations

Collateral Sensitivity and Cross-Resistance

1984 • 16 citations

N-Methyl-N-nitrosourea potentiation of cytogenetic damage induced by 1,3-bis(2-chloroethyl)-1-nitrosourea in normal human lymphocytes.

1985 • 16 citations

Comparison of sister-chromatid exchange induction caused by nitrosoureas that alkylate or alkylate and crosslink DNA

1985 • 15 citations