Human liver oxidative metabolism of O6-benzylguanine

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

[6] Statistical analysis of enzyme kinetic data

1979 • 2,002 citations

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

1992 • 932 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

1989 • 303 citations

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

1990 • 280 citations

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O‐deethylation of phenacetin and is inducible by cigarette smoking.

1988 • 236 citations

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

1991 • 229 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Caffeine as a metabolic probe: Exploration of the enzyme-inducing effect of cigarette smoking

1991 • 214 citations

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

1993 • 214 citations

A comparison of the distribution and electron acceptor specificities of xanthine oxidase and aldehyde oxidase

1974 • 177 citations

Molybdenum Hydroxylases as Drug-Metabolizing Enzymes

1985 • 147 citations

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.

1992 • 105 citations

Enhancement of Nitrosourea Activity in Medulloblastoma and Glioblastoma Multiforme

1992 • 102 citations

Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects

1988 • 90 citations

[8] Expression of mammalian cytochrome P450 using vaccinia virus

1991 • 76 citations

Synergistic efficacy of O6benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone

1993 • 72 citations

Treatment of subcutaneous and intracranial brain tumor xenografts withO 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea

1993 • 70 citations

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-BIS(2-chloroethyl)-1-nitrosourea(BCNU)

1993 • 58 citations

Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.

1994 • 54 citations

Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro

1994 • 48 citations

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