Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Applied Nonparametric Statistics

1991 • 5,126 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.

1990 • 736 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.

1977 • 297 citations

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

1991 • 229 citations

The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis

1985 • 224 citations

DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.

1980 • 151 citations

Cross-linking of DNA induced by chloroethyinitrosourea is prevented by O⁶-methyiguanine-DNA methyttransferase

1983 • 137 citations

Correlation between O⁶-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N′-nitro-N-nitrosoguanidine

1984 • 119 citations

Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.

1984 • 97 citations

Modulation of Mammalian O⁶-Alkylguanine-DNA Alkyltransferase in vivo by O⁶-Benzylguanine and its Effect on the Sensitivity of a Human Glioma Tumor to l-(2-chloroethyl)-3-(4-methylcyclohexyl)-l-nitrosourea

1990 • 95 citations

Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.

1986 • 86 citations

Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.

1985 • 69 citations

Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.

1986 • 67 citations

Potentiation of nitrosourea cytotoxicity in human leukemic cells by inactivation of O6-alkylguanine-DNA alkyltransferase.

1988 • 63 citations

Inhibition of a Specific DNA Repair System and Nitrosourea Cytotoxicity in Resistant Human Cancer Cells

1989 • 61 citations

Use of antibodies to human O⁶-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O⁶-benzylguanine or N-methyl-N′-nitro-N-nitrosoguanidine

1991 • 59 citations

Exposure of HeLa cells to 06-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents

1985 • 54 citations

The cytotoxic and mutagenic effects of alkylating agents on human lymphoid cells are caused by different DNA lesions

1985 • 51 citations

Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair.

1985 • 44 citations

Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine

1989 • 39 citations

Modulation of human lymphocyte O6-alkylguanine-DNA alkyltransferase by streptozotocin in vivo.

1989 • 39 citations

Inhibition of the hepatic o6-alkylguanine-DNA alkyltransferase in vivo by pretreatment with antineoplastic agents

1989 • 36 citations

ChemInform Abstract: ALLYLIC REARRANGEMENT FROM O6 TO C-8 IN THE GUANINE SERIES

1973 • 2 citations