Activin A Is a Potent Activator of Renal Interstitial Fibroblasts

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Evidence that fibroblasts derive from epithelium during tissue fibrosis

2002 • 1,792 citations

BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

2003 • 1,308 citations

Pathophysiology of Progressive Nephropathies

1998 • 1,250 citations

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

1990 • 1,002 citations

Activin-Binding Protein from Rat Ovary Is Follistatin

1990 • 886 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

RELATIONSHIP BETWEEN RENAL FUNCTION AND HISTOLOGICAL CHANGES FOUND IN RENAL-BIOPSY SPECIMENS FROM PATIENTS WITH PERSISTENT GLOMERULAR NEPHRITIS

1968 • 652 citations

Molecular insights into renal interstitial fibrosis.

1996 • 636 citations

Connective tissue growth factor mediates transforming growth factor β‐induced collagen synthesis: down‐regulation by cAMP

1999 • 623 citations

Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions.

1988 • 553 citations

Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

1993 • 525 citations

Transforming growth factor-β regulates tubular epithelial-myofibroblast transdifferentiation in vitro

1999 • 476 citations

Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation

2002 • 466 citations

Blockage of Tubular Epithelial to Myofibroblast Transition by Hepatocyte Growth Factor Prevents Renal Interstitial Fibrosis

2002 • 327 citations

Activins, Inhibins, and Follistatins: Further Thoughts on a Growing Family of Regulators

1997 • 298 citations

Increased expression of TGF-β1 mRNA in the obstructed kidney of rats with unilateral ureteral ligation

1993 • 295 citations

Significance of Tubulointerstitial Changes in the Renal Cortex for the Excretory Function and Concentration Ability of the Kidney: A Morphometric Contribution

1987 • 294 citations

Follistatin Binds to both Activin and Inhibin through the Common Beta-Subunit

1991 • 258 citations

Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells

2003 • 252 citations

Matrix Metalloproteinases in Renal Development and Disease

2000 • 249 citations

TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)

2001 • 248 citations

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction

2000 • 247 citations

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy

2002 • 228 citations

Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.

1996 • 224 citations

Bone Morphogenetic Protein-7 Improves Renal Fibrosis and Accelerates the Return of Renal Function

2002 • 222 citations

Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse

1995 • 212 citations

Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair

1999 • 209 citations

Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts

1997 • 208 citations

Myofibroblasts and the progression of diabetic nephropathy

1997 • 199 citations

The role of vasoactive compounds, growth factors and cytokines in the progression of renal disease

2000 • 193 citations

Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation

2000 • 184 citations

A Novel Role of Follistatin, an Activin-binding Protein, in the Inhibition of Activin Action in Rat Pituitary Cells

1997 • 183 citations

Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis

2001 • 171 citations

Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells.

1991 • 167 citations

Role of connective tissue growth factor in profibrotic action of transforming growth factor-β: A potential target for preventing renal fibrosis

2001 • 145 citations

Renal Interstitial Fibrosis Is Reduced in Angiotensin II Type 1a Receptor-Deficient Mice

2001 • 143 citations

The tissue distribution of activin beta A- and beta B-subunit and follistatin messenger ribonucleic acids suggests multiple sites of action for the activin-follistatin system during human development.

1994 • 136 citations

Role of fibroblast activation in inducing interstitial fibrosis.

2000 • 134 citations

A transient rise in cytosolic calcium follows stimulation of quiescent cells with growth factors and is inhibitable with phorbol myristate acetate.

1985 • 121 citations

Expression of activin A is increased in cirrhotic and fibrotic rat livers

1998 • 92 citations

Involvement of Pax-2 in the Action of Activin A on Tubular Cell Regeneration

2002 • 89 citations

Involvement of the Activin-Follistatin System in Tubular Regeneration after Renal Ischemia in Rats

2001 • 86 citations

Interstitial Myof ibroblasts in Experimental Renal Infection and Scarring

1995 • 80 citations

Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis.

1996 • 78 citations

Activins and Activin Receptors in Cell Growth

1997 • 78 citations

Immunohistochemical Localization of Follistatin in Rat Tissues.

1991 • 64 citations

Hepatocyte growth factor induces branching tubulogenesis in MDCK cells by modulating the activin-follistatin system

2000 • 54 citations

Expression of immunoreactive and bioactive activin A protein in adult murine lung after bleomycin treatment.

1995 • 52 citations

Activin: a novel player in tissue repair processes.

1999 • 48 citations

Activin A: An autocrine regulator of cell growth and differentiation in renal proximal tubular cells

2002 • 45 citations

Role of Ras Isoforms in the Stimulated Proliferation of Human Renal Fibroblasts in Primary Culture

2000 • 39 citations

Number of Glomeruli Is Increased in the Kidney of Transgenic Mice Expressing the Truncated Type II Activin Receptor

2000 • 30 citations