Inhibition of TGF‐β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine‐induced liver fibrosis

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

Role of Transforming Growth Factor β in Human Disease

2000 • 2,405 citations

TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders

2000 • 2,354 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7

2002 • 1,572 citations

Histologic fixatives suitable for diagnostic light and electron microscopy.

1976 • 1,272 citations

Signal Transduction by the TGF-β Superfamily

2002 • 1,255 citations

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody indb/dbdiabetic mice

2000 • 907 citations

Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.

1991 • 794 citations

Cloning of a TGF$beta; type I receptor that forms a heteromeric complex with the TGF$beta; type II receptor

1993 • 779 citations

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.

1992 • 675 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections.

1985 • 615 citations

Inhibition of Transforming Growth Factor (TGF)-β1–Induced Extracellular Matrix with a Novel Inhibitor of the TGF-β Type I Receptor Kinase Activity: SB-431542

2002 • 609 citations

Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

1996 • 559 citations

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

1999 • 433 citations

SIRIUS RED F3BA AS A STAIN FOR CONNECTIVE TISSUE.

1964 • 430 citations

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.

1996 • 423 citations

Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

2002 • 415 citations

Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers

2002 • 405 citations

Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy

1999 • 341 citations

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

2002 • 306 citations

Follistatin: A Multifunctional Regulatory Protein

1998 • 267 citations

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.

1987 • 247 citations

Inhibition of transforming growth factorβ prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats

2000 • 243 citations

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

2003 • 231 citations

Targeting TGF-β overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade

1998 • 222 citations

Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen

2001 • 197 citations

Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters

1999 • 188 citations

Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin

2001 • 184 citations

Characterization of a Bone Morphogenetic Protein-responsive Smad-binding Element

2000 • 182 citations

Multiple transforming growth factor-beta-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells.

1991 • 158 citations

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

1996 • 147 citations

Role of Elevated Plasma Transforming Growth Factor-β1 Levels in Wound Healing

1999 • 139 citations

2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis

1995 • 131 citations

Prediction of progressive liver fibrosis in hepatitis C infection by serum and tissue levels of transforming growth factor‐β

2001 • 122 citations

Increased expression of plasminogen activator and plasminogen activator inhibitor during liver fibrogenesis of rats: role of stellate cells

1999 • 120 citations

Hostophotometric estimation of volume density of collagen as an indication of fibrosis in rat liver

1986 • 94 citations

Relationship between procollagen III aminoterminal propeptide and hyaluronan serum levels and histological fibrosis in primary biliary cirrhosis and chronic viral hepatitis C

1994 • 94 citations

Adenoviral expression of a transforming growth factor-β1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats

2003 • 84 citations

Transforming growth factor-β1 in autoimmune hepatitis: correlation of liver tissue expression and serum levels with disease activity

1998 • 84 citations

Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine

2000 • 84 citations

Negative regulation of gene expression by TGF‐β

1992 • 71 citations

Animal Models of Liver Fibrosis

1996 • 61 citations

Histological features predictive of liver fibrosis in chronic hepatitis C infection.

1996 • 43 citations

Adenovirus-mediated overexpression of follistatin enlarges intact liver of adult rats

2003 • 41 citations

The Effects of Hepatic Fibrosis on Ito Cell Gene Expression

1992 • 34 citations

Serum hyaluronan as a marker of liver fibrosis in asymptomatic chronic viral hepatitis B

1999 • 31 citations

Anti-transforming growth factor-β1 antibody improves survival rate following partial hepatectomy in cirrhotic rats

2002 • 14 citations