The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

2003 • 5,611 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer

2003 • 1,572 citations

Role of Transforming Growth Factor Beta in Human Cancer

2005 • 703 citations

Development of TGF-β signalling inhibitors for cancer therapy

2004 • 536 citations

Structural Interaction Fingerprint (SIFt): A Novel Method for Analyzing Three-Dimensional Protein−Ligand Binding Interactions

2003 • 529 citations

Crystal Structure of the Cytoplasmic Domain of the Type I TGF β Receptor in Complex with FKBP12

1999 • 433 citations

Structural basis of inhibitor selectivity in MAP kinases

1998 • 408 citations

SD-208, a Novel Transforming Growth Factor β Receptor I Kinase Inhibitor, Inhibits Growth and Invasiveness and Enhances Immunogenicity of Murine and Human Glioma CellsIn vitroandIn vivo

2004 • 407 citations

Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

1998 • 309 citations

The ALK‐5 inhibitor A‐83‐01 inhibits Smad signaling and epithelial‐to‐mesenchymal transition by transforming growth factor‐β

2005 • 306 citations

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

2003 • 231 citations

Overexpression of Transforming Growth Factor β1 in Head and Neck Epithelia Results in Inflammation, Angiogenesis, and Epithelial Hyperproliferation

2004 • 191 citations

Dual Role of Transforming Growth Factor β in Mammary Tumorigenesis and Metastatic Progression

2005 • 169 citations

Successful shape-Based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)

2003 • 161 citations

Transforming Growth Factor-β

2005 • 152 citations

Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

2005 • 137 citations

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

2007 • 110 citations

Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation.

1996 • 109 citations

Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment

2004 • 108 citations

Interaction Profiles of Protein Kinase−Inhibitor Complexes and Their Application to Virtual Screening

2004 • 95 citations

Overexpression of activin A in stage IV colorectal cancer

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Mechanism of Poly(A) Polymerase: Structure of the Enzyme-MgATP-RNA Ternary Complex and Kinetic Analysis

2007 • 87 citations

TGF-β inhibitors for the treatment of cancer

2005 • 83 citations

Concomitant over-expression of activin/inhibin β subunits and their receptors in human pancreatic cancer

1998 • 61 citations

Inhibin Resistance Is Associated with Aggressive Tumorigenicity of Ovarian Cancer Cells

2005 • 60 citations

Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice

2005 • 59 citations

Interference with TGF‐β1 and ‐β3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma

2002 • 53 citations

Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma

2005 • 53 citations

Protein kinase inhibition: natural and synthetic variations on a theme

1997 • 52 citations

Transforming the TGFbeta pathway: convergence of distinct lead generation strategies on a novel kinase pharmacophore for TbetaRI (ALK5).

2004 • 40 citations

Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE)

2001 • 38 citations

Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma

2000 • 35 citations

Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation

1996 • 29 citations

Activated type I TGFbeta receptor (Alk5) kinase confers enhanced survival to mammary epithelial cells and accelerates mammary tumor progression

2005 • 8 citations

Knowledge = power

2003 • 5 citations

Different routes to the same answer

2003 • 3 citations