Structural and Enzymatic Aspects of Rhodopsin Phosphorylation

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Recoverin: a Calcium Sensitive Activator of Retinal Rod Guanylate Cyclase

1991 • 569 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

CHELATOR: an improved method for computing metal ion concentrations in physiological solutions.

1992 • 443 citations

Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites

1982 • 441 citations

Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

1988 • 409 citations

Rhodopsin phosphorylation as a mechanism of cyclic GMP phosphodiesterase regulation by S-modulin

1993 • 401 citations

Structure and function of receptors coupled to G proteins

1994 • 377 citations

A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment

1994 • 338 citations

Biochemistry and Physiology of Visual Pigments

1973 • 320 citations

Mechanism of rhodopsin kinase activation

1991 • 301 citations

Mechanisms of Rhodopsin Inactivation in Vivo as Revealed by a COOH-Terminal Truncation Mutant

1995 • 299 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

The calcium feedback signal in the phototransduction cascade of vertebrate rods

1994 • 290 citations

[8] Preparation of retinal rod outer segments

1982 • 279 citations

Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase

1995 • 278 citations

A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy.

1991 • 264 citations

Signal flow in visual transduction

1992 • 238 citations

The role of arrestin and retinoids in the regeneration pathway of rhodopsin.

1992 • 217 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

A 26 kd calcium binding protein from bovine rod outer segments as modulator of photoreceptor guanylate cyclase.

1991 • 198 citations

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

1991 • 189 citations

Inactivation of photoexcited rhodopsin in retinal rods: the roles of rhodopsin kinase and 48-kDa protein (arrestin)

1988 • 185 citations

Rhodopsin Phosphorylation and Dephosphorylation in Vivo

1995 • 176 citations

Rod Outer Segment Retinol Dehydrogenase: Substrate Specificity and Role in Phototransduction

1994 • 171 citations

The catalytic subunits of protein phosphatase‐1 and protein phosphatase 2A are distinct gene products

1984 • 160 citations

[23] Purification of rhodopsin by concanavalin A affinity chromatography

1982 • 157 citations

Mass spectrometric identification of phosphorylation sites in bleached bovine rhodopsin

1993 • 140 citations

Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin.

1993 • 139 citations

Regulation of Rhodopsin Dephosphorylation by Arrestin

1989 • 134 citations

Palmitylation of a G-protein coupled receptor. Direct analysis by tandem mass spectrometry.

1992 • 134 citations

Phosphorylation sites in bovine rhodopsin

1993 • 129 citations

Light-dependent phosphorylation of rhodopsin in living frogs

1974 • 128 citations

The distribution and proportions of vitamin A compounds during the visual cycle in the rat

1974 • 126 citations

Interaction of rhodopsin with the G‐protein, transducin

1993 • 125 citations

Interaction between photoactivated rhodopsin and its kinase: Stability and kinetics of complex formation

1993 • 122 citations

Duration and Amplitude of the Light-Induced cGMP Hydrolysis in Vertebrate Photoreceptors Are Regulated by Multiple Phosphorylation of Rhodopsin and by Arrestin Binding

1995 • 120 citations

Mechanistic studies on the phosphorylation of photoexcited rhodopsin

1988 • 105 citations

Involvement of protein kinase C in the phosphorylation of rhodopsin.

1991 • 98 citations

Inhibition of Rhodopsin Phosphorylation by Non-Myristoylated Recombinant Recoverin

1994 • 95 citations

Control of Rhodopsin Multiple Phosphorylation

1994 • 95 citations

Characterization of a truncated form of arrestin isolated from bovine rod outer segments

1994 • 92 citations

Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors.

1993 • 90 citations

Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange

1994 • 89 citations

The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin

1989 • 86 citations

Isolation and identification of the phosphorylated species of rhodopsin

1984 • 81 citations

Phosphorylation of rhodopsin by protein kinase C in vitro.

1986 • 81 citations

Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations

1989 • 80 citations

Identification of the autophosphorylation sites in rhodopsin kinase.

1992 • 72 citations

Synthetic phosphopeptides are substrates for casein kinase II

1990 • 72 citations

Fluorescence Studies of the Location and Membrane Accessibility of the Palmitoylation Sites of Rhodopsin

1994 • 64 citations

Depalmitylation with hydroxylamine alters the functional properties of rhodopsin.

1991 • 61 citations

Rhodopsin Kinase Autophosphorylation

1995 • 61 citations

Interplay of phosphorylation and dephosphorylation in vision: protein phosphatases of bovine rod outer segments

1989 • 61 citations

Photoreceptor light-adaptation mediated by S-modulin, a member of a possible regulatory protein family of protein phosphorylation in signal transduction

1994 • 59 citations

Preparing Rod Outer Segment Membranes, Regenerating Rhodopsin, and Determining Rhodopsin Concentration

1993 • 56 citations

Recoverin mediates the calcium effect upon rhodopsin phosphorylation and cGMP hydrolysis in bovine retina rod cells

1994 • 56 citations

Cooperativity during multiple phosphorylations catalyzed by rhodopsin kinase: supporting evidence using synthetic phosphopeptides

1993 • 56 citations

Calcium‐sensitive control of rhodopsin phosphorylation in the reconstituted system consisting of photoreceptor membranes, rhodopsin kinase and recoverin

1994 • 52 citations

Identification and characterization of protein kinase C zeta-immunoreactive proteins.

1994 • 51 citations

A synthetic peptide substrate specific for casein kinase‐1

1989 • 47 citations

Nucleoside inhibitors of rhodopsin kinase

1990 • 44 citations

Activation of rhodopsin phosphorylation is triggered by the lumirhodopsin–metarhodopsin I transition

1983 • 41 citations

Kinetics and Localization of the Phosphorylation of Rhodopsin by Protein Kinase C

1995 • 31 citations

The phospho‐opsin Phosphatase from Bovine Rod Outer Segments

1994 • 29 citations

A Metal-Dependent Form of Protein Phosphatase 2A

1995 • 25 citations

Rhodopsin mutation proline³⁴⁷-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347

1995 • 21 citations

The Kinetics of Multiphosphorylation of Rhodopsin

1993 • 20 citations

Purification of Rhodopsin Kinase from Bovine Rod Outer Segments

1993 • 20 citations

Rhodopsin kinase: Studies on the sequence of and the recognition motif for multiphosphorylations

1994 • 19 citations

Phosphorylatio of solubilised dark‐adapted rhodopsin

1993 • 19 citations

Illumination of bovine photoreceptor membranes causes phosphorylation of both bleached and unbleached rhodopsin molecules

1986 • 19 citations

Calcium-Binding Proteins in the Retina

1993 • 18 citations

Preparation and Characterization of Protein Kinase C from Rod Outer Segments

1993 • 10 citations