Stereoisomeric Specificity of the Retinoid Cycle in the Vertebrate Retina

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Short-chain dehydrogenases/reductases (SDR)

1995 • 1,228 citations

Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice

1999 • 854 citations

Mutations in RPE65 cause autosomal recessive childhood–onset severe retinal dystrophy

1997 • 645 citations

Mutations in the RPE65 gene in patients with autosomal recessive retinitis pigmentosa or Leber congenital amaurosis

1998 • 460 citations

Characteristics of short‐chain alcohol dehydrogenases and related enzymes

1991 • 452 citations

Interactions of retinoid binding proteins and enzymes in retinoid metabolism

1999 • 410 citations

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

1999 • 351 citations

The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily

1997 • 297 citations

Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina

1996 • 287 citations

[8] Preparation of retinal rod outer segments

1982 • 279 citations

Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus

1999 • 279 citations

Cyclic GMP and calcium: The internal messengers of excitation and adaptation in vertebrate photoreceptors

1990 • 258 citations

Binding of substrate in a ternary complex of horse liver alcohol dehydrogenase.

1982 • 255 citations

The Retinal Pigment Epithelial-specific 11-cis Retinol Dehydrogenase Belongs to the Family of Short Chain Alcohol Dehydrogenases

1995 • 250 citations

Signal flow in visual transduction

1992 • 238 citations

Regulation of sensitivity in vertebrate rod photoreceptors by calcium

1996 • 237 citations

Molecular Genetics of Human Retinal Disease

1999 • 232 citations

Expression Cloning and Characterization of Oxidative 17β- and 3α-Hydroxysteroid Dehydrogenases from Rat and Human Prostate

1997 • 227 citations

Identification and Characterization of All-trans-retinol Dehydrogenase from Photoreceptor Outer Segments, the Visual Cycle Enzyme That Reduces All-trans-retinal to All-trans-retinol

2000 • 204 citations

Molecular Characterization of a Novel Short-chain Dehydrogenase/Reductase That Reduces All-trans-retinal

1998 • 182 citations

Rod Outer Segment Retinol Dehydrogenase: Substrate Specificity and Role in Phototransduction

1994 • 171 citations

Membranes as the Energy Source in the Endergonic Transformation of Vitamin A to 11- cis -Retinol

1989 • 159 citations

Biochemical aspects of the visual process

1975 • 153 citations

Ca2+-binding proteins in the retina: Structure, function, and the etiology of human visual diseases

2000 • 153 citations

THE STEREOSPECIFICITY OF ENZYMATIC HYDROGEN TRANSFER FROM DIPHOSPHOPYRIDINE NUCLEOTIDE

1957 • 146 citations

Preferential Release of 11-cis-retinol from Retinal Pigment Epithelial Cells in the Presence of Cellular Retinaldehyde-binding Protein

1999 • 132 citations

THE REDUCTION OF RETINENE1 TO VITAMIN A1 IN VITRO

1949 • 131 citations

Disruption of the 11-cis-Retinol Dehydrogenase Gene Leads to Accumulation of cis-Retinols andcis-Retinyl Esters

2000 • 124 citations

cDNA Cloning and Characterization of a New Human Microsomal NAD+-dependent Dehydrogenase that Oxidizes All-trans-retinol and 3α-Hydroxysteroids

1998 • 112 citations

Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man

2000 • 107 citations

Identification and Characterization of a Stereospecific Human Enzyme That Catalyzes 9-cis-Retinol Oxidation

1997 • 107 citations

Regulation of Isomerohydrolase Activity in the Visual Cycle

1998 • 97 citations

A new cubic-space section model for predicting the specificity of horse liver alcohol dehydrogenase-catalyzed oxidoreductions

1982 • 97 citations

[19] High-performance liquid chromatography analysis of visual cycle retinoids

2000 • 97 citations

The identification of a 9- cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9- cis retinoic acid

1998 • 94 citations

cDNA Cloning and Characterization of a cis-Retinol/3α-Hydroxysterol Short-chain Dehydrogenase

1997 • 88 citations

Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue

1999 • 81 citations

METABOLISM OF GLUCOSE AND REDUCTION OF RETINALDEHYDE IN RETINAL PHOTORECEPTORS¹

1970 • 81 citations

11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus.

1999 • 76 citations

cDNA Cloning, Tissue Distribution, and Substrate Characteristics of a cis-Retinol/3α-Hydroxysterol Short-chain Dehydrogenase Isozyme

1998 • 67 citations

Site-directed Mutagenesis of Putative Substrate-binding Residues Reveals a Mechanism Controlling the Different Stereospecificities of Two Tropinone Reductases

1999 • 66 citations

Cloning and expression of a cDNA encoding bovine retinal pigment epithelial 11-CIS retinol dehydrogenase.

1995 • 63 citations

Intracellular localization and membrane topology of 11-cis retinol dehydrogenase in the retinal pigment epithelium suggest a compartmentalized synthesis of 11-cis retinaldehyde

1999 • 59 citations

Stereoselective Carveol Dehydrogenase from Rhodococcus erythropolis DCL14

1999 • 54 citations

Conversion of mammalian 3α-hydroxysteroid dehydrogenase to 20α-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins

1999 • 50 citations

Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/reductase able to catalyze cis-retinol oxidation

1999 • 50 citations

QUANTITATIVE HISTOCHEMISTRY OF NICOTINAMIDE ADENINE NUCLEOTIDES IN RETINA OF MONKEY AND RABBIT¹

1968 • 50 citations

The visual cycle retinol dehydrogenase: possible involvement in the 9‐cis retinoic acid biosynthetic pathway

1998 • 42 citations

Conformations of nicotinamide coenzymes bound to dehydrogenases determined by transferred nuclear Overhauser effects

1983 • 42 citations

Substrate specificities and 13-cis-retinoic acid inhibition of human, mouse and bovine cis-retinol dehydrogenases

2000 • 33 citations

Stereochemical inversion at C-15 accompanies the enzymic isomerization of all-trans- to 11-cis-retinoids

1988 • 33 citations

Retinol dehydrogenase from bovine retinal rod outer segments. Kinetic mechanism of the solubilized enzyme.

1982 • 32 citations

Identification and immunohistochemistry of retinol dehydrogenase from bovine retinal pigment epithelium

1993 • 28 citations

Methods for Producing Recombinant Human Cellular Retinaldehyde-Binding Protein

1998 • 27 citations

Subcellular distribution of 11-cis retinol dehydrogenase activity in bovine pigment epithelium

1976 • 27 citations

Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes

1998 • 26 citations

[21] Multienzyme analysis of visual cycle

2000 • 23 citations

Concise encyclopedia biochemistry and molecular biology

1997 • 19 citations

[23] Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases

2000 • 12 citations

Stereochemistry of the visual cycle

1989 • 12 citations

Enzymatic In Situ Analysis by 1H-NMR of the Hydrogen Transfer Stereospecificity of NAD(P)+-Dependent Dehydrogenases1

1989 • 7 citations

A one-step pmr determination of hydrogen transfer stereospecificity of NADP+-linked oxidoreductases

1983 • 6 citations

[22] Analyzing membrane topology of 11-cis-retinol dehydrogenase

2000 • 4 citations