Rhodopsin Mutants That Bind But Fail to Activate Transducin

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

1986 • 1,264 citations

Cyclic GMP Cascade of Vision

1986 • 1,168 citations

Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin

1983 • 689 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

The structure of bovine rhodopsin

1983 • 513 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.

1987 • 444 citations

Two adjacent cysteine residues in the C‐terminal cytoplasmic fragment of bovine rhodopsin are palmitylated

1988 • 409 citations

Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.

1988 • 409 citations

Three cytoplasmic loops of rhodopsin interact with transducin.

1989 • 370 citations

Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core

1987 • 318 citations

A single amino acid substitution in rhodopsin (lysine 248—-leucine) prevents activation of transducin.

1988 • 260 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

Preparation and Properties of Phospholipid Bilayers Containing Rhodopsin

1972 • 252 citations

The structure of rhodopsin and the rod outer segment disk membrane

1983 • 248 citations

Total synthesis of a gene for bovine rhodopsin.

1986 • 179 citations

Specific amino acid substitutions in bacterioopsin: Replacement of a restriction fragment in the structural gene by synthetic DNA fragments containing altered codons

1984 • 158 citations

Light-induced binding of guanosinetriphosphatase to bovine photoreceptor membranes: effect of limited proteolysis of the membranes

1981 • 136 citations

Site-directed mutagenesis of human beta-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase.

1988 • 131 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

Repair of the Escherichia coli chromosome after in vivo scission by the EcoRI endonuclease.

1989 • 92 citations

Shift in the relation between flash‐induced metarhodopsin I and metarhodopsin II within the first 10% rhodopsin bleaching in bovine disc membranes

1981 • 70 citations

Staphylococcus aureus alpha-toxin attack on human platelets promotes assembly of the prothrombinase complex.

1990 • 66 citations

Mapping sites of interaction between rhodopsin and transducin using rhodopsin antipeptide antibodies.

1988 • 59 citations

Photoactivation of rhodopsin and interaction with transducin in detergent micelles

1989 • 51 citations

Deoxylysolecithin and a new biphenyl detergent as solubilizing agents for bovine rhodopsin. Functional test by formation of metarhodopsin II and binding of G-protein

1987 • 30 citations