Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism.

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Role of endothelium-derived nitric oxide in the regulation of blood pressure.

1989 • 1,837 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Multiple System Organ Failure

1980 • 751 citations

NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.

1990 • 657 citations

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

1989 • 612 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Peptide Regulatory Factors

1989 • 498 citations

The discovery of nitric oxide as the endogenous nitrovasodilator.

1988 • 486 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Identification of arginine as a precursor of endothelium-derived relaxing factor.

1988 • 407 citations

Synthesis of nitrite and nitrate in murine macrophage cell lines.

1987 • 335 citations

Mediators produced by the endothelial cell.

1988 • 329 citations

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit

1989 • 279 citations

Tumor necrosis factor induces glomerular damage in the rabbit.

1989 • 244 citations

Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

1989 • 238 citations

Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide

1989 • 220 citations

FAD and GSH participate in macrophage synthesis of nitric oxide

1990 • 182 citations

A rapid method for the assay of nitrate in urine using the nitrate reductase enzyme of Escherichia coli

1984 • 138 citations

Second messenger role for NO widens to nervous and immunesystem

1989 • 135 citations

SHORT COMMUNICATION: Cytokines Induce an L-Arginine-Dependent Effector System in Nonmacrophage Cells

1988 • 133 citations

Interleukin 1 inhibits contraction of vascular smooth muscle.

1989 • 126 citations

Effects of endothelium-derived relaxing factor and nitric oxide on rat mesangial cells

1990 • 126 citations

L-arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo

1989 • 126 citations

Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation

1989 • 126 citations

Cachectin/TNF as well as interleukin-1 induces prostacyclin synthesis in cultured vascular endothelial cells

1986 • 124 citations

Tumor necrosis factor-mediated cytotoxicity involves ADP-ribosylation.

1988 • 113 citations

Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. Association with vascular cytokine release.

1990 • 102 citations

Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.

1988 • 101 citations

Mitogenic and cytotoxic actions of tumor necrosis factor in BALB/c 3T3 cells

1989 • 98 citations

Glomerular endothelial cells respond to calcium-mobilizing agonists with release of EDRF

1990 • 98 citations

Does Endothelium-Derived Nitric Oxide Have a Rolein Cytokine-Induced Hypotension?

1990 • 89 citations

Glomerular mesangial cells in local inflammation. Induction of the expression of MHC class II antigens by IFN-gamma.

1989 • 73 citations

Antiproliferative activity of gamma-interferon combined with lipopolysaccharide on murine adenocarcinoma: dependence on an L-arginine metabolism with production of nitrite and citrulline.

1989 • 64 citations

Retraction

1991 • 60 citations

Dissociation of systemic and renal effects in endotoxemia. Prostaglandin inhibition uncovers an important role of renal nerves.

1982 • 56 citations