Synergism between tumor necrosis factor‐α and interferon‐γ on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide‐dependent mechanism

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage Cytotoxicity: Role for L-Arginine Deiminase and Imino Nitrogen Oxidation to Nitrite

1987 • 1,533 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Recombinant mouse gamma interferon induces the priming step in macrophage activation for tumor cell killing.

1983 • 447 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Activation of macrophages in vivo and in vitro. Correlation between hydrogen peroxide release and killing of Trypanosoma cruzi.

1979 • 334 citations

Nonspecific defence mechanism: the role of nitric oxide

1991 • 325 citations

Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis.

1989 • 256 citations

Macrophage Activation for Tumor Cytotoxicity: Development of Macrophage Cytotoxic Activity Requires Completion of A Sequence of Short-Lived Intermediary Reactions

1978 • 252 citations

Immunity to Trypanosoma cruzi

1980 • 203 citations

<scp>L</scp>‐Arginine‐dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation

1991 • 184 citations

Tumor necrosis factor‐α in combination with interferon‐γ, but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotes

1990 • 179 citations

Functional heterogeneity of CD4+ T cells in leishmaniasis

1989 • 171 citations

Macrophage activation for tumor cytotoxicity: characterization of priming and trigger signals during lymphokine activation.

1981 • 154 citations

Activity of recombinant tumor necrosis factor on Toxoplasma gondii and Trypanosoma cruzi.

1986 • 143 citations

Oxygen-derived Free Radicals in the Pathogenesis of Parasitic Disease

1986 • 143 citations

Interferon γ and lymphotoxin or tumor necrosis factor act synergistically to induce macrophage killing of tumor cells and schistosomula of schistosoma mansoni

1987 • 132 citations

Use of cloned populations of mouse lymphocytes to analyze cellular differentiation

1981 • 88 citations

Synergistic protection by specific antibodies and interferon against infection by Trypanosoma cruzi in vitro

1984 • 87 citations

The respiratory burst is not required for killing of intracellular and extracellular parasites by a lymphokine‐activated macrophage cell line

1985 • 78 citations

Oxidative killing of intracellular parasites mediated by macrophages

1988 • 71 citations

Recombinant tumor necrosis factor enhances macrophage destruction of Trypanosoma cruzi in the presence of bacterial endotoxin.

1988 • 62 citations

Interferon-gamma synergizes with tumor necrosis factor and with interleukin 1 and requires the presence of both monokines to induce antitumor cytotoxic activity in macrophages.

1987 • 61 citations

Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells.

1987 • 50 citations

Trypanosoma cruzi: induction of microbicidal activity in human mononuclear phagocytes.

1982 • 43 citations

Lymphokine activation of J774G8 cells and mouse peritoneal macrophages challenged with Toxoplasma gondii

1985 • 39 citations

Growth of Trypanosoma cruzi in a cloned macrophage cell line and in a variant defective in oxygen metabolism

1983 • 36 citations

Enhancement of susceptibility of HSV-1-infected cells to natural killer lysis by interferon.

1983 • 22 citations

A colorimetric assay based on cell viability for the indirect detection of intracellular replication and killing of Trypanosoma cruzi

1987 • 20 citations

Activation by synergism between endotoxin and lymphokines of the mouse macrophage cell line J774 against infection by Trypanosoma cruzi

1987 • 18 citations

Activation of the Na⁺/K⁺‐ATPase by interleukin‐2

1986 • 14 citations

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