Osteoblasts are target cells for transformation in c-fos transgenic mice

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements

1987 • 2,107 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure

1987 • 1,771 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

The c-fos protein interacts with c-JunAP-1 to stimulate transcription of AP-1 responsive genes

1988 • 1,352 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Bone and haematopoietic defects in mice lacking c-fos

1992 • 939 citations

Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences

1985 • 871 citations

Mineralized bone nodules formedin vitro from enzymatically released rat calvaria cell populations

1986 • 855 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene

1984 • 601 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts

1988 • 578 citations

Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini

1983 • 532 citations

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos

1987 • 523 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells

1990 • 515 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Cells of bone: proliferation, differentiation, and hormonal regulation

1986 • 479 citations

Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression.

1990 • 467 citations

1,25(OH) ₂ ‐Vitamin D ₃ receptors: gene regulation and genetic circuitry

1988 • 455 citations

Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain

1988 • 455 citations

1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene

1989 • 418 citations

Nuclear Proto-Oncogenes Fos and Jun

1990 • 392 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

Deregulated c-fos expression interferes with normal bone development in transgenic mice

1987 • 337 citations

Tissue specificity and developmental expression of rat osteopontin

1987 • 317 citations

Virus Induction of Osteosarcomas in Mice

1966 • 314 citations

Physiological Concentrations of Glucocorticoids Stimulate Formation of Bone Nodules from Isolated Rat Calvaria Cellsin Vitro

1987 • 311 citations

Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes

1984 • 303 citations

The effect of 1,25(OH)2D3 on alkaline phosphatase in osteoblastic osteosarcoma cells.

1982 • 300 citations

Growth Factors Regulate Transin Gene Expression by c- fos -Dependent and c- fos -Independent Pathways

1988 • 290 citations

Transgenic Models of Tumor Development

1991 • 289 citations

Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1

1989 • 286 citations

The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation

1989 • 286 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

Fos-IacZ transgenic mice: Mapping sites of gene induction in the central nervous system

1992 • 237 citations

Dissecting Multistep Tumorigenesis in Transgenic Mice

1988 • 215 citations

Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.

1990 • 209 citations

Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation.

1989 • 205 citations

c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages

1986 • 204 citations

Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter

1990 • 189 citations

Trans-repression of the mouse c-fos promoter: A novel mechanism of fos-mediated trans-regulation

1989 • 187 citations

Mouse major histocompatibility class I gene expression begins at midsomite stage and is inducible in earlier-stage embryos by interferon.

1985 • 185 citations

c-fos expression induces bone tumors in transgenic mice.

1989 • 177 citations

Positive and negative immunoselection for enrichment of two classes of osteoprogenitor cells.

1991 • 173 citations

Analysis of the differentiation-promoting potential of inducible c-fos genes introduced into embryonal carcinoma cells.

1985 • 173 citations

Enhanced expression of TGF-β and c-fos mRNAs in the growth plates of developing human long bones

1988 • 173 citations

Tissue-specific expression of c-jun and junB during organogenesis in the mouse

1989 • 172 citations

A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumours in embryonic stem cell chimeras.

1991 • 172 citations

The murine gene encoding secreted phosphoprotein 1 (osteopontin): promoter structure, activity, and induction in vivo by estrogen and progesterone

1991 • 169 citations

The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation.

1991 • 163 citations

Differential expression of c-fos in hematopoietic cells: correlation with differentiation of monomyelocytic cells in vitro.

1984 • 158 citations

Tumor suppressor genes

1993 • 147 citations

The proto-oncogene c-fos is over-expressed in the majority of human osteosarcomas.

1990 • 135 citations

Proto-oncogene c-fos expression in growth regions of fetal bone and mesodermal web tissue

1987 • 133 citations

Detection of fos protein during osteogenesis by monoclonal antibodies.

1988 • 123 citations

Rat Calvarial Cell Lines Immortalized with SV-40 Large T Antigen: Constitutive and Retinoic Acid- Inducible Expression of Osteoblastic Features

1989 • 121 citations

High Incidence of Lung, Bone, and Lymphoid Tumors in Transgenic Mice Overexpressing Mutant Alleles of the p53 Oncogene

1989 • 109 citations

Phenotype suppression: A postulated molecular mechanism for mediating the relationship of proliferation and differentiation by Fos/Jun interactions at AP‐1 sites in steroid responsive promoter elements of tissue‐specific genes

1991 • 89 citations

Phenotype-Associated Changes in the Effects of 1,25-Dihydroxyvitamin D₃on Alkaline Phosphatase and Bone GLA-Protein of Rat Osteoblastic Cells*

1986 • 84 citations

c-fos expression interferes with thymus development in transgenic mice

1988 • 84 citations

v-Src and EJ Ras alleviate repression of c-Jun by a cell-specific inhibitor

1991 • 81 citations

Growth Factor Inducible Genes in Fibroblasts

1990 • 81 citations

Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice.

1986 • 74 citations

c-fos expression precedes osteogenic differentiation of cartilage cells in vitro.

1990 • 71 citations

Growth and differentiation of embryonic stem cells that lack an intact c-fos gene.

1992 • 67 citations

Evidence for Heterogeneity of the Osteoblastic Phenotype Determined with Clonal Rat Bone Cells Established from Transforming Growth Factor-β- Induced Cell Colonies Grown Anchorage Independently in Semisolid Medium*

1989 • 62 citations

c-fos Proto-Oncogene Expression in the Nervous System during Mouse Development

1989 • 59 citations

Identification of Fos target genes by the use of selective induction systems

1992 • 54 citations

An immortalized osteogenic cell line derived from mouse teratocarcinoma is able to mineralize in vivo and in vitro.

1990 • 51 citations

A Burst of c-fos Gene Expression in the Mouse Occurs at Birth

1987 • 51 citations

Characterization of a new human osteosarcoma cell line OHS-4 [published erratum appears in J Cell Biol 1991 Oct;115(1):279]

1991 • 44 citations

The Glucocorticoid Receptor Binds to a Sequence Overlapping the TATA Box of the Human Osteocalcin Promoter: a Potential Mechanism for Negative Regulation

1991 • 43 citations

Fracture healing induces expression of the proto‐oncogene c‐fos in vivo Possible involvement of the Fos protein in osteoblastic differentiation

1991 • 42 citations

Behind the Fos and Jun leucine zipper.

1989 • 42 citations

Sympathetic hyperplasia and neuroblastomas in transgenic mice expressing polyoma middle T antigen.

1990 • 41 citations

EXPRESSION OF THE c‐fos PROTO‐ONCOGENE IN BONE, CARTILAGE AND TOOTH FORMING TISSUES DURING MOUSE DEVELOPMENT

1988 • 40 citations

Stable murine chondrogenic cell lines derived from c-fos-induced cartilage tumors

1993 • 38 citations

Transcriptional regulation in the testis: a role for transcription factor AP-1 complexes at various stages of spermatogenesis.

1993 • 37 citations

Histogenesis and Morphology of periosteal sarcomas induced by FBJ virus in NIH Swiss mice.

1976 • 35 citations

Elevated c‐fos expression inhibits differentiation of L6 rat myoblasts

1989 • 31 citations

Expression of protooncogenes in murine osteosarcomas

1986 • 30 citations

Characterization of fos-induced osteogenic tumours and tumour-derived murine cell lines

1990 • 23 citations

Morphology and in vivo growth characteristics of an atypical murine proliferative osseous lesion induced in vitro.

1986 • 23 citations

Stage and tissue-specific expression of fosB during mouse development

1991 • 20 citations

Detection of fos Protein during Osteogenesis by Monoclonal Antibodies

1988 • 19 citations

In vivo Studies of the FBJ Murine Osteosarcoma Virus

1969 • 17 citations

Elevated p53 RNA expression correlates with incomplete osteogenic differentiation of radiation‐induced murine osteosarcomas

1992 • 16 citations

C-fos oncogene expression in dexamethasone stimulated osteogenic cells in chick embryo periosteal cultures

1991 • 13 citations

Transcriptional Regulation of Proto-Oncogene c-fos

1989 • 12 citations

The proto-oncogene c-fos: structure, expression, and functional aspects.

1989 • 10 citations

Immunocytochemical demonstratin of c‐fos protein in sertoli cells and germ cells in rat testis

1991 • 9 citations

The Specific Consequences of c-fos Expression in Transgenic Mice

1989 • 7 citations

The Introduction of Genes into Mouse Embryos and Stem Cells

1992 • 6 citations

c-fos ONCOGENE EXPRESSION IN CARTILAGE AND BONE TISSUES OF TRANSGENIC AND CHIMERIC MICE

1993 • 6 citations