The Hormonal Control of Food Intake

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

2013 • 8,227 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

2012 • 3,329 citations

Hypothalamic regulation of sleep and circadian rhythms

2005 • 2,613 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Diet-induced insulin resistance in mice lacking adiponectin/ACRP30

2002 • 2,081 citations

The biology of incretin hormones

2006 • 2,029 citations

Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

2003 • 1,665 citations

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

2003 • 1,617 citations

Anatomy and regulation of the central melanocortin system

2005 • 1,511 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,312 citations

Leptin-Replacement Therapy for Lipodystrophy

2002 • 1,201 citations

Interleukin-6-deficient mice develop mature-onset obesity

2002 • 1,197 citations

Trophic Action of Leptin on Hypothalamic Neurons That Regulate Feeding

2004 • 1,188 citations

Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

2005 • 1,136 citations

Obesity Wars

2004 • 1,119 citations

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

2005 • 1,053 citations

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

2002 • 1,051 citations

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

2004 • 975 citations

Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters

2005 • 949 citations

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

2004 • 895 citations

Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice

2003 • 892 citations

Recombinant Human Leptin in Women with Hypothalamic Amenorrhea

2004 • 877 citations

Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding

2006 • 872 citations

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

2003 • 858 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome

2005 • 758 citations

Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis

2006 • 747 citations

Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

2001 • 738 citations

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

2004 • 699 citations

Clinical and Molecular Genetic Spectrum of Congenital Deficiency of the Leptin Receptor

2007 • 680 citations

Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance

2005 • 669 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2004 • 632 citations

Deletion of Ghrelin Impairs neither Growth nor Appetite

2003 • 631 citations

Mice lacking ghrelin receptors resist the development of diet-induced obesity

2005 • 621 citations

Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists

2005 • 621 citations

Leptin Regulation of the Mesoaccumbens Dopamine Pathway

2006 • 615 citations

Neuronal PTP1B regulates body weight, adiposity and leptin action

2006 • 603 citations

Critical role for peptide YY in protein-mediated satiation and body-weight regulation

2006 • 596 citations

A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

2004 • 584 citations

Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

2002 • 573 citations

Attenuated Peptide YY Release in Obese Subjects Is Associated with Reduced Satiety

2005 • 531 citations

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

2004 • 496 citations

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3

2004 • 489 citations

The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight

2006 • 479 citations

Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene

2006 • 460 citations

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference

2004 • 455 citations

Ghrelin action in the brain controls adipocyte metabolism

2006 • 449 citations

GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin

2006 • 417 citations

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

2006 • 399 citations

Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

2006 • 399 citations

Minireview: Glucocorticoids—Food Intake, Abdominal Obesity, and Wealthy Nations in 2004

2004 • 396 citations

Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance

2006 • 394 citations

Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

2002 • 374 citations

A War on Obesity, Not the Obese

2003 • 371 citations

Absence of ghrelin protects against early-onset obesity

2005 • 370 citations

Gastrointestinal hormones regulating appetite

2006 • 325 citations

Induction of leptin resistance through direct interaction of C-reactive protein with leptin

2006 • 319 citations

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

2001 • 313 citations

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

2006 • 307 citations

Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice.

2000 • 304 citations

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

2004 • 291 citations

Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents

2006 • 265 citations

Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats

2003 • 246 citations

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

2006 • 241 citations

The role of leptin receptor signaling in feeding and neuroendocrine function

2003 • 236 citations

The role of insulin receptor substrate 2 in hypothalamic and β cell function

2005 • 231 citations

Proopiomelanocortin and Energy Balance: Insights from Human and Murine Genetics

2004 • 228 citations

Vaccination against weight gain

2006 • 224 citations

A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance

2006 • 224 citations

Prevalence, Spectrum, and Functional Characterization of Melanocortin-4 Receptor Gene Mutations in a Representative Population-Based Sample and Obese Adults from Germany

2006 • 210 citations

Peripheral administration of PYY3–36 produces conditioned taste aversion in mice

2005 • 185 citations

A role for β-melanocyte-stimulating hormone in human body-weight regulation

2006 • 180 citations

Prevalence of Mutations and Functional Analyses of Melanocortin 4 Receptor Variants Identified among 750 Men with Juvenile-Onset Obesity

2005 • 174 citations

Insulin in the brain: a hormonal regulator of energy balance

1992 • 167 citations

Regulation of Ghrelin in Physiologic and Pathophysiologic States

2005 • 160 citations

Triiodothyronine Stimulates Food Intake via the Hypothalamic Ventromedial Nucleus Independent of Changes in Energy Expenditure

2004 • 158 citations

Agouti-related protein-deficient mice display an age-related lean phenotype

2005 • 126 citations

Divergent Regulation of Proopiomelanocortin Neurons by Leptin in the Nucleus of the Solitary Tract and in the Arcuate Hypothalamic Nucleus

2006 • 124 citations

Late-Onset Leanness in Mice with Targeted Ablation of Melanin Concentrating Hormone Neurons

2006 • 119 citations

Sim1 Haploinsufficiency Impairs Melanocortin-Mediated Anorexia and Activation of Paraventricular Nucleus Neurons

2006 • 115 citations

Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice.

2000 • 103 citations

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

2006 • 90 citations

Recombinant Human Leptin in Women With Hypothalamic Amenorrhea

2005 • 79 citations

Multilevel regulation of leptin storage, turnover, and secretion by feeding and insulin in rat adipose tissue

2006 • 69 citations

Prevalence and functionality of paucimorphic and privateMC4Rmutations in a large, unselected European British population, scanned by meltMADGE

2006 • 63 citations

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

2006 • 61 citations

AgRP in energy balance: Will the real AgRP please stand up?

2006 • 58 citations

Adrenalectomy Alters the Sensitivity of the Central Nervous System Melanocortin System

2003 • 50 citations

Isoproterenol decreases leptin release from rat and human adipose tissue through posttranscriptional mechanisms

2004 • 44 citations