Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

The Continuing Epidemics of Obesity and Diabetes in the United States

2001 • 2,803 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

2000 • 2,178 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

2004 • 895 citations

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excision

2000 • 841 citations

Diabetes, Obesity, and the Brain

2005 • 840 citations

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

1988 • 743 citations

Agouti-related peptide–expressing neurons are mandatory for feeding

2005 • 738 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 731 citations

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

2004 • 716 citations

Properties and functions of ATP-sensitive K-channels

1990 • 690 citations

The Significance of Basal Insulin Levels in the Evaluation of the Insulin Response to Glucose in Diabetic and Nondiabetic Subjects*

1967 • 664 citations

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

1997 • 631 citations

Role for neuronal insulin resistance in neurodegenerative diseases

2004 • 601 citations

The role of insulin receptor signaling in the brain

2005 • 584 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

1986 • 572 citations

Membrane Phospholipid Control of Nucleotide Sensitivity of K _ATP Channels

1998 • 569 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

1992 • 533 citations

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

1999 • 502 citations

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

2001 • 467 citations

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

2003 • 458 citations

Quantitative study of insulin secretion and clearance in normal and obese subjects.

1988 • 438 citations

The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins

2002 • 406 citations

PI3K integrates the action of insulin and leptin on hypothalamic neurons

2005 • 382 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

Overfeeding Rapidly Induces Leptin and Insulin Resistance

2001 • 353 citations

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1999 • 349 citations

Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus.

1999 • 347 citations

Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express K_ATPChannels

2003 • 341 citations

Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats

2003 • 327 citations

Insulin-Binding Sites in the Rat Brain: In Vivo Localization to the Circumventricular Organs by Quantitative Radioautography*

1979 • 319 citations

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

1999 • 316 citations

Insulin in the Cerebrospinal Fluid

1967 • 283 citations

In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin*

2000 • 234 citations

The role of insulin receptor substrate 2 in hypothalamic and β cell function

2005 • 231 citations

Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

1997 • 226 citations

Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family

2000 • 193 citations

PI3K integrates the action of insulin and leptin on hypothalamic neurons

2005 • 190 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin

1992 • 172 citations

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.

2004 • 162 citations

Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3-Kinase–Dependent Pathway

2001 • 146 citations

Peripheral Hyperinsulinemia Promotes Tau Phosphorylation In Vivo

2005 • 139 citations

Nucleotides and phospholipids compete for binding to the C terminus of K _ATP channels

2002 • 130 citations

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

2002 • 130 citations

Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression

1995 • 115 citations

Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing

2000 • 103 citations

In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin

2000 • 80 citations

Impaired glucose signaling as a cause of obesity and the metabolic syndrome: The glucoadipostatic hypothesis

2005 • 72 citations

Leptin activation of ATP‐sensitive K⁺ (K_ATP) channels in rat CRI‐G1 insulinoma cells involves disruption of the actin cytoskeleton

2000 • 71 citations

Cholecystokinin Tunes Firing of an Electrically Distinct Subset of Arcuate Nucleus Neurons by Activating A-Type Potassium Channels

2002 • 60 citations

GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area

1992 • 57 citations

Mice with deletion of the mitochondrial glycerol-3-phosphate dehydrogenase gene exhibit a thrifty phenotype: effect of gender

2004 • 32 citations

Insulin and Leptin Combine Additively to Reduce Food Intake and Body Weight in Rats

2002 • 30 citations

The role of insulin receptor substrate 2 in hypothalamic and β cell function

2005 • 21 citations

Gender difference in the leptin response to feeding in peroxisome-proliferator-activated receptor-alpha knockout mice

2002 • 17 citations

The role for neuronal insulin resistance in neurodegenerative diseases

2004 • 7 citations