Antisense RNA Down-Regulation of bcl-2 Expression in DU145 Prostate Cancer Cells Does Not Diminish the Cytostatic Effects of G3139 (Oblimersen)

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

RNAi

2000 • 2,596 citations

Gene silencing in mammals by small interfering RNAs

2002 • 1,403 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Bcl‐2 family: Life‐or‐death switch

2000 • 665 citations

Methods of Detection of Vascular Reactive Species

2001 • 547 citations

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1998 • 496 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

2000 • 487 citations

Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells.

1995 • 422 citations

Bcl-2 family proteins and mitochondria

1998 • 374 citations

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

1995 • 323 citations

Constitutive expression of human Bcl-2 modulates nitrogen mustard and camptothecin induced apoptosis.

1993 • 275 citations

bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways.

1993 • 238 citations

bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.

1993 • 218 citations

Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction ofbcl-2 Gene Expression

1994 • 190 citations

Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells

2000 • 180 citations

Gene Silencing Mediated by Small Interfering RNAs in Mammalian Cells

2003 • 161 citations

RNA-mediated gene silencing

2003 • 136 citations

RNAi: gene-silencing in therapeutic intervention

2002 • 134 citations

High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.

1994 • 128 citations

Targeting bcl-2 gene to delay androgen-independent progression and enhance chemosensitivity in prostate cancer using antisense bcl-2 oligodeoxynucleotides

1999 • 102 citations

Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 antisense oligonucleotides

2002 • 90 citations

Development of a hammerhead ribozyme against bcl-2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone-refractory human prostate cancer

1997 • 86 citations

Inhibition of Potentially Anti-Apoptotic Proteins by Antisense Protein Kinase C-α (Isis 3521) and Antisense bcl-2 (G3139) Phosphorothioate Oligodeoxynucleotides: Relationship to the Decreased Viability of T24 Bladder and PC3 Prostate Cancer Cells

2001 • 61 citations

G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner.

2003 • 47 citations

A recombinant defective adenoviral agent expressing anti-bcl-2 ribozyme promotes apoptosis of bcl-2-expressing human prostate cancer cells

1999 • 47 citations

Development of a hammerhead ribozyme against BCL-2. II. Ribozyme treatment sensitizes hormone-resistant prostate cancer cells to apoptotic agents.

1997 • 45 citations

Antisense Bcl‐2 Retrovirus Vector Increases the Sensitivity of a Human Gastric Adenocarcinoma Cell Line to Photodynamic Therapy

1999 • 45 citations

Antisense RNA down-regulation of bcl-xL Expression in prostate cancer cells leads to diminished rates of cellular proliferation and resistance to cytotoxic chemotherapeutic agents.

2002 • 40 citations

Caspase involved synergistic cytotoxicity of bcl-2 antisense oligonucleotides and Adriamycin on transitional cell cancer cells

2000 • 35 citations

Bcl-2 regulates chondrocyte morphology and aggrecan gene expression independent of caspase activation and full apoptosis

1999 • 34 citations

The Long and Short of siRNAs

2002 • 30 citations

Changes in Gene Expression Induced by Phosphorothioate Oligodeoxynucleotides (Including G3139) in PC3 Prostate Carcinoma Cells Are Recapitulated at Least in Part by Treatment with Interferon-β and -γ

2004 • 28 citations

Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is enhanced by N-(2-hydroxyphenyl)all-trans retinamide

1998 • 24 citations