RNAi: gene-silencing in therapeutic intervention

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

Identification of Novel Genes Coding for Small Expressed RNAs

2001 • 4,834 citations

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

2001 • 3,225 citations

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

2000 • 2,945 citations

An Extensive Class of Small RNAs in Caenorhabditis elegans

2001 • 2,806 citations

RNAi

2000 • 2,596 citations

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans.

1990 • 2,386 citations

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

2001 • 1,779 citations

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 • 1,526 citations

Use of dsRNA-Mediated Genetic Interference to Demonstrate that frizzled and frizzled 2 Act in the Wingless Pathway

1998 • 1,116 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

2001 • 1,055 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

2002 • 965 citations

Post-transcriptional gene silencing by double-stranded RNA

2001 • 833 citations

Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1

2002 • 833 citations

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways

2000 • 832 citations

Systemic acquired silencing: transgene-specific post-transcriptional silencing is transmitted by grafting from silenced stocks to non-silenced scions

1997 • 777 citations

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

2002 • 716 citations

U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells

2002 • 715 citations

Double-stranded RNA induces mRNA degradation inTrypanosomabrucei

1998 • 705 citations

RNA interference—2001

2001 • 698 citations

RNAi in C. elegans : Soaking in the Genome Sequence

1998 • 635 citations

RNA-triggered gene silencing

1999 • 623 citations

Stable suppression of gene expression by RNAi in mammalian cells

2002 • 549 citations

RNAi: nature abhors a double-strand

2002 • 509 citations

Heritable gene silencing in Drosophila using double-stranded RNA

2000 • 503 citations

RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing

2002 • 449 citations

Chalcone synthase cosuppression phenotypes in petunia flowers: comparison of sense vs. antisense constructs and single-copy vs. complex T-DNA sequences

1996 • 384 citations

RNAi as Random Degradative PCR

2001 • 370 citations

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action.

2000 • 370 citations

Post-transcriptional gene silencing across kingdoms

2000 • 353 citations

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

2002 • 305 citations

Consistent gene silencing in transgenic plants expressing a replicating potato virus X RNA

1997 • 242 citations

Double-Stranded RNA Injection Produces Null Phenotypes in Zebrafish

2000 • 155 citations

Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.

2001 • 151 citations

An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene

2001 • 147 citations

RNAi in Mouse Oocytes and Preimplantation Embryos: Effectiveness of Hairpin dsRNA

2001 • 130 citations

RNA viruses as inducers, suppressors and targets of post-transcriptional gene silencing.

2000 • 119 citations

Functional genomics and target validation approaches using antisense oligonucleotide technology

2001 • 82 citations

Gene targeting via triple-helix formation

2001 • 80 citations

Post-transcriptional suppression of gene expression in Xenopus embryos by small interfering RNA

2002 • 69 citations

RNA as a drug target: methods for biophysical characterization and screening

2000 • 69 citations

Gene Therapy: Optimising DNA Delivery to the Nucleus

2001 • 62 citations

Characterization of a new class of DNA delivery complexes formed by the local anesthetic bupivacaine

2000 • 41 citations

Biomira, Merck in vaccine deal

2001 • 31 citations

US FTC probes practices of 100 companies

2001 • 22 citations

Self-assembling complexes for in vivo gene delivery.

2000 • 19 citations