A recombinant defective adenoviral agent expressing anti-bcl-2 ribozyme promotes apoptosis of bcl-2-expressing human prostate cancer cells

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Detection of the apoptosis-suppressing oncoprotein bc1-2 in hormone-refractory human prostate cancers.

1993 • 597 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells

1994 • 571 citations

Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo.

1995 • 537 citations

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

1995 • 323 citations

Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

1997 • 221 citations

An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis

1999 • 221 citations

p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene.

1997 • 183 citations

Bcl-2 Family Proteins: Strategies for Overcoming Chemoresistance in Cancer

1997 • 127 citations

Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme.

1995 • 110 citations

The expression of drug resistance gene products during the progression of human prostate cancer.

1998 • 108 citations

Development of a hammerhead ribozyme against bcl-2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone-refractory human prostate cancer

1997 • 86 citations

Development of a hammerhead ribozyme against BCL-2. II. Ribozyme treatment sensitizes hormone-resistant prostate cancer cells to apoptotic agents.

1997 • 45 citations

Bcl-2 Family Proteins and the Hormonal Control of Cell Life and Death in Normalcy and Neoplasia

1997 • 26 citations