J Proteins Catalytically Activate Hsp70 Molecules to Trap a Wide Range of Peptide Sequences

Protein folding in the cell

1992 • 4,138 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

1996 • 1,247 citations

Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding

1992 • 965 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

1997 • 797 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

1993 • 650 citations

DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage.

1993 • 593 citations

Role of auxilin in uncoating clathrin-coated vesicles

1995 • 495 citations

Kinetics of Molecular Chaperone Action

1994 • 440 citations

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.

1990 • 435 citations

Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p

1995 • 400 citations

The J-domain family and the recruitment of chaperone power

1998 • 396 citations

Mitochondrial Hsp70/MIM44 complex facilitates protein import

1994 • 391 citations

ATP-induced protein Hsp70 complex dissociation requires K+ but not ATP hydrolysis

1993 • 366 citations

Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

1991 • 359 citations

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

1996 • 346 citations

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor σ32

1992 • 314 citations

A zinc finger-like domain of the molecular chaperone DnaJ is involved in binding to denatured protein substrates.

1996 • 304 citations

A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.

1989 • 296 citations

A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.

1993 • 290 citations

Different conformations for the same polypeptide bound to chaperones DnaK and GroEL

1992 • 285 citations

The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication.

1994 • 285 citations

A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32.

1996 • 281 citations

Role of the J-domain in the cooperation of Hsp40 with Hsp70

1998 • 279 citations

Can Hsp70 proteins act as force-generating motors?

1995 • 270 citations

The emergence of the chaperone machines

1992 • 249 citations

Specificity of DnaK-peptide Binding

1994 • 244 citations

A Bipartite Signaling Mechanism Involved in DnaJ-mediated Activation of the Escherichia coli DnaK Protein

1996 • 222 citations

Zuotin, a ribosome-associated DnaJmolecular chaperone

1998 • 170 citations

The 58,000-Dalton Cellular Inhibitor of the Interferon-Induced Double-Stranded RNA-Activated Protein Kinase (PKR) Is a member of the Tetratricopeptide Repeat Family of Proteins

1994 • 162 citations

The Lumenal Domain of Sec63p Stimulates the ATPase Activity of BiP and Mediates BiP Recruitment to the Translocon in Saccharomyces cerevisiae

1997 • 151 citations

NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain.

1994 • 147 citations

Protein Transport by Purified Yeast Sec Complex and Kar2p Without Membranes

1997 • 146 citations

In Vitro Dissociation of BiP-Peptide Complexes Requires a Conformational Change in BiP after ATP Binding but Does Not Require ATP Hydrolysis

1995 • 143 citations

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins.

1994 • 136 citations

Ordered Assembly of Nucleoprotein Structures at the Bacteriophage λ Replication Origin during the Initiation of DNA Replication

1989 • 135 citations

Mechanism of clathrin basket dissociation: separate functions of protein domains of the DnaJ homologue auxilin.

1996 • 131 citations

The power stroke of the DnaK/DnaJ/GrpE molecular chaperone system 1 1Edited by J.Karn

1997 • 114 citations

Post-translational protein translocation: not all hsc70s are created equal

1996 • 100 citations

The DnaJ chaperone catalytically activates the DnaK chaperone to preferentially bind the sigma 32 heat shock transcriptional regulator.

1995 • 91 citations

The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function

1997 • 90 citations

ATP Hydrolysis Is Required for the DnaJ-dependent Activation of DnaK Chaperone for Binding to Both Native and Denatured Protein Substrates

1995 • 69 citations

Real Time Kinetics of the DnaK/DnaJ/GrpE Molecular Chaperone Machine Action

1996 • 57 citations

Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae.

1993 • 56 citations