Structure of a Bag/Hsc70 Complex: Convergent Functional Evolution of Hsp70 Nucleotide Exchange Factors

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

1995 • 5,246 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

The Hsp70 and Hsp60 Chaperone Machines

1998 • 2,793 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

The structural basis of the activation of Ras by Sos

1998 • 765 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Superconducting Single Crystals of Tl2Ba2CaCu2O8 and YBa2Cu4O8: Crystal Structures in the Vicinity of Tc

1998 • 543 citations

The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE.

1994 • 520 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators

1999 • 509 citations

Crystal Structure of the Nucleotide Exchange Factor GrpE Bound to the ATPase Domain of the Molecular Chaperone DnaK

1997 • 489 citations

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome

2000 • 478 citations

Getting Newly Synthesized Proteins into Shape

2000 • 426 citations

GrpE-like regulation of the Hsc70 chaperone by the anti-apoptotic protein BAG-1

1997 • 397 citations

The Role of ATP in the Functional Cycle of the DnaK Chaperone System

1995 • 388 citations

ATP-induced protein Hsp70 complex dissociation requires K+ but not ATP hydrolysis

1993 • 366 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

Regulation of Hsp70 function by a eukaryotic DnaJ homolog.

1992 • 262 citations

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23

2000 • 230 citations

The Second Step of ATP Binding to DnaK Induces Peptide Release

1996 • 219 citations

Structural insights into substrate binding by the molecular chaperone DnaK.

2000 • 190 citations

BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release

1998 • 179 citations

GrpE Accelerates Nucleotide Exchange of the Molecular Chaperone DnaK with an Associative Displacement Mechanism

1997 • 171 citations

Mammalian protein RAP46: an interaction partner and modulator of 70kDa heat shock proteins

1997 • 157 citations

Interaction of BAG-1 with Retinoic Acid Receptor and Its Inhibition of Retinoic Acid-induced Apoptosis in Cancer Cells

1998 • 131 citations

Characterization of Interactions between the Anti-apoptotic Protein BAG-1 and Hsc70 Molecular Chaperones

1998 • 103 citations

Kinetics of Nucleotide-Induced Changes in the Tryptophan Fluorescence of the Molecular Chaperone Hsc70 and Its Subfragments Suggest the ATP-Induced Conformational Change Follows Initial ATP Binding

1995 • 61 citations

The crystal structure of Tm₅Re₂O₁₂

1999 • 51 citations