Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1994 • 2,575 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

1995 • 862 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria

1994 • 577 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints

1995 • 509 citations

Mechanism of interaction between Ku protein and DNA.

1986 • 485 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene

1995 • 386 citations

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1995 • 370 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

ICE-like proteases in apoptosis

1995 • 353 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.

1995 • 342 citations

Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.

1993 • 311 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

1995 • 278 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

An essential gene, ESR1, is required for mitotic growth, DNA repair and meiotic recombination Saccharomyces cerevisiae

1994 • 215 citations

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks.

1994 • 215 citations

Sequence-specific DNA binding by Ku autoantigen and its effects on transcription

1996 • 211 citations

Analysis of the mechanism of interaction of simian Ku protein with DNA

1991 • 207 citations

Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts.

1985 • 143 citations

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

1995 • 138 citations

DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I.

1995 • 121 citations

The cell cycle: A practical approach

1994 • 114 citations

Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA.

1992 • 98 citations

ANTIBODIES TO THE p70/p80 (Ku) ANTIGENS IN SYSTEMIC LUPUS ERYTHEMATOSUS

1992 • 89 citations

The recognition of DNA damage

1996 • 81 citations

On the mechanisms of ku protein binding to DNA

1992 • 80 citations

Isolation and characterization of the Schizosaccharomyces pombe rad3 gene, involved in the DNA damage and DNA synthesis checkpoints

1992 • 76 citations

Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.

1995 • 71 citations

The 86-kDa subunit of autoantigen Ku is a somatostatin receptor regulating protein phosphatase-2A activity

1994 • 63 citations

Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.

1995 • 57 citations

Cell Cycle — Materials and Methods

1996 • 53 citations

Bcl-2 regulates activation of apoptotic proteases in a cell-free system

1996 • 49 citations

Cancer Predisposition: Ataxia–telangiectasia at the crossroads

1995 • 48 citations

A protein homologous to human Ku p70-protein is required for reconstitution ofXenopus sperm pronuclei

1993 • 11 citations

Preparation of Xenopus Egg Extracts and Their Utilization in Cell Cycle Studies

1996 • 7 citations