Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C

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Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

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Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

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Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

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Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

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A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

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Cbl-b Is a Negative Regulator of Receptor Clustering and Raft Aggregation in T Cells

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T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1

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NF-κB activation induced by TCR/CD28 costimulation is mediated by PKC-θ

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The Phosphoinositide-dependent Kinase, PDK-1, Phosphorylates Conventional Protein Kinase C Isozymes by a Mechanism That Is Independent of Phosphoinositide 3-Kinase

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The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte–antigen-presenting cell interface

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The Carboxyl Terminus of Protein Kinase C Provides a Switch to Regulate Its Interaction with the Phosphoinositide-dependent Kinase, PDK-1

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Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex

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Protein Kinase Cθ Cooperates with Calcineurin to Induce Fas Ligand Expression During Activation-Induced T Cell Death

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Dual Role of Pseudosubstrate in the Coordinated Regulation of Protein Kinase C by Phosphorylation and Diacylglycerol

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Site-directed mutagenesis reveals a novel catalytic mechanism of Mycobacterium tuberculosis alkylhydroperoxidase C

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Vav Synergizes with Protein Kinase CΘ to Mediate IL-4 Gene Expression in Response to CD28 Costimulation in T Cells

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Vav modulation of the Ras / MEK / ERK signaling pathway plays a role in NFAT activation and CD69 up-regulation

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2000 • 46 citations

Protein Kinase C θ Cooperates with Vav1 to Induce JNK Activity in T-cells

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A phospholipase C inhibitor, U-73122, blocks TSH-induced inositol trisphosphate production, Ca2+ increase and arachidonic acid release in FRTL-5 thyroid cells

1994 • 21 citations

Effects of an aminosteroid inhibitor of phospholipase C-dependent processes on the TCR-mediated signal transduction pathway in human T cells

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