Synergistic Activation of NF-κB by Functional Cooperation between Vav and PKCθ in T Lymphocytes

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling

2000 • 927 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Ionizing radiation and short wavelength UV activate NF-κB through two distinct mechanisms

1998 • 431 citations

The IKK complex: an integrator of all signals that activate NF-κB?

2000 • 400 citations

From TCR Engagement to T Cell Activation

1999 • 379 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex

2000 • 323 citations

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

1993 • 306 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

T cell clonal anergy

1997 • 257 citations

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

1999 • 239 citations

A Novel Functional Interaction between Vav and PKCθ Is Required for TCR-Induced T Cell Activation

2000 • 226 citations

Sequential DNA damage-independent and -dependent activation of NF-kappa B by UV

1998 • 225 citations

The Proto-Oncogene Cot Kinase Participates in CD3/CD28 Induction of NF-κB Acting through the NF-κB-Inducing Kinase and IκB Kinases

1999 • 208 citations

Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation

1999 • 188 citations

Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

2000 • 170 citations

Direct Interaction between Protein Kinase Cθ (PKCθ) and 14-3-3τ in T Cells: 14-3-3 Overexpression Results in Inhibition of PKCθ Translocation and Function†

1996 • 158 citations

Regulation of Protein Kinase Cθ Function during T Cell Activation by Lck-mediated Tyrosine Phosphorylation

2000 • 118 citations

Protein kinase Cθ, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

1999 • 113 citations

Vav Regulates Peptide-specific Apoptosis in Thymocytes

1998 • 104 citations

A Guanine Nucleotide Exchange Factor-independent Function of Vav1 in Transcriptional Activation

2000 • 103 citations

Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex

2000 • 102 citations

Involvement of Jun and Rel Proteins in Up-regulation of Interleukin-4 Gene Activity by the T Cell Accessory Molecule CD28

1998 • 82 citations

Vav Synergizes with Protein Kinase CΘ to Mediate IL-4 Gene Expression in Response to CD28 Costimulation in T Cells

2000 • 58 citations

Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription

2000 • 35 citations

Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.

1999 • 32 citations

Primary Human CD4+ T Cells Contain Heterogeneous IκB Kinase Complexes: Role in Activation of the IL-2 Promoter

1999 • 30 citations

Antibody-Induced CD3–CD4 Coligation Inhibits TCR/CD3 Activation in the Absence of Costimulatory Signals in Normal Mouse CD4+ T Lymphocytes

1999 • 8 citations