Pharmacogenetics of the human beta-adrenergic receptors

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

Complex promoter and coding region β ₂ -adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

2000 • 971 citations

Amino-Terminal Polymorphisms of the Human .beta.2-Adrenergic Receptor Impart Distinct Agonist-Promoted Regulatory Properties

1994 • 780 citations

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

2002 • 768 citations

Mutations in the Gene Encoding for the β₂-adrenergic Receptor in Normal and Asthmatic Subjects

1993 • 633 citations

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.

1997 • 624 citations

Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial

2004 • 606 citations

Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β₃-Adrenergic–Receptor Gene

1995 • 602 citations

A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor

1999 • 588 citations

Synergistic Polymorphisms of β₁- and α_2C-Adrenergic Receptors and the Risk of Congestive Heart Failure

2002 • 537 citations

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.

1993 • 470 citations

Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function.

1997 • 418 citations

The Effect of Common Polymorphisms of the β₂-Adrenergic Receptor on Agonist-Mediated Vascular Desensitization

2001 • 361 citations

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.

1998 • 350 citations

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

2003 • 332 citations

Upregulation of β ₃ -Adrenoceptors and Altered Contractile Response to Inotropic Amines in Human Failing Myocardium

2001 • 312 citations

The Expanding Spectrum of G Protein Diseases

1999 • 288 citations

Altered Beta-adrenergic Receptor Gene Regulation and Signaling in Chronic Heart Failure

2001 • 280 citations

Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression.

1998 • 278 citations

Adrenergic Nervous System in Heart Failure

1997 • 232 citations

The Myocardium-protective Gly-49 Variant of the β1-Adrenergic Receptor Exhibits Constitutive Activity and Increased Desensitization and Down-regulation

2002 • 224 citations

Ascaris lumbricoides Infection Is Associated with Increased Risk of Childhood Asthma and Atopy in Rural China

2002 • 223 citations

Amino Acid 49 Polymorphisms of the Human β 1 -Adrenergic Receptor Affect Agonist-Promoted Trafficking

2002 • 211 citations

A novel polymorphism in the gene coding for the beta1-adrenergic receptor associated with survival in patients with heart failure

2000 • 211 citations

The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis.

1994 • 210 citations

Changes in myocardial and vascular receptors in heart failure

1993 • 199 citations

β3-Adrenoceptors in the cardiovascular system

2000 • 188 citations

Polymorphism in the β ₁ -Adrenergic Receptor Gene and Hypertension

2001 • 185 citations

Regional Distribution of β-Adrenoceptors in the Human Heart

1986 • 181 citations

Polymorphisms of the β ₂ -Adrenergic Receptor Determine Exercise Capacity in Patients With Heart Failure

2000 • 179 citations

Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.

1996 • 177 citations

??1-Adrenergic receptor polymorphisms and left ventricular remodeling changes in response to ??-blocker therapy

2005 • 175 citations

Positional Genomic Analysis Identifies the β ₂ -Adrenergic Receptor Gene as a Susceptibility Locus for Human Hypertension

2000 • 171 citations

A Polymorphism in the β1 Adrenergic Receptor Is Associated with Resting Heart Rate

2002 • 160 citations

The human β3-adrenoceptor: the search for a physiological function

1994 • 160 citations

Time to draw breath: asthma-susceptibility genes are identified

2004 • 154 citations

Meta-analysis of the association of β2-adrenergic receptor polymorphisms with asthma phenotypes

2005 • 148 citations

�-Adrenoceptor polymorphisms

2004 • 144 citations

Pharmacogenetics of Beta-1- and Beta-2-Adrenergic Receptors

2000 • 140 citations

??-Adrenoceptor genotype influences the response to carvedilol in patients with congestive heart failure

2003 • 137 citations

Future Research Directions in Asthma. An NHLBI Working Group Report

2015 • 135 citations

β₂-Adrenergic Receptor Pharmacogenetics

2000 • 132 citations

Meta-analysis of the association of the Trp64Arg polymorphism in the β3 adrenergic receptor with body mass index

1998 • 128 citations

Pharmacogenetics of Asthma

2002 • 125 citations

The tissue distribution of the human β3-adrenoceptor studied using a monoclonal antibody: Direct evidence of the β3-adrenoceptor in human adipose tissue, atrium and skeletal muscle

1999 • 123 citations

Adrenoceptor genes in human obesity

1999 • 122 citations

Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals.

1999 • 122 citations

β-adrenergic Receptor Polymorphisms and Responses during Titration of Metoprolol Controlled Release/extended Release in Heart Failure*

2005 • 121 citations

Ser49Gly of β-adrenergic receptor is associated with effective β-blocker dose in dilated cardiomyopathy

2005 • 110 citations

Characterization of a Unique Genetic Variant in the β1-adrenoceptor Gene and Evaluation of its Role in Idiopathic Dilated Cardiomyopathy

1999 • 109 citations

Racial differences in the frequencies of cardiac ?1-adrenergic receptor polymorphisms: Analysis of c145A>G and c1165G>C

1999 • 106 citations

The promoter and intron/exon structure of the human and mouse β3‐adrenergic‐receptor genes

1993 • 100 citations

Hurst's the Heart

2001 • 96 citations

β1-Adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?

2000 • 96 citations

Genomic Approaches to Understanding Asthma

2000 • 91 citations

Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.

1992 • 88 citations

β 2 -Adrenergic Receptor Gene Variation and Hypertension in Subjects With Type 2 Diabetes

2001 • 86 citations

Beta₁‐adrenergic receptor gene polymorphisms and response to Beta₁‐adrenergic receptor blockade in patients with essential hypertension

2004 • 80 citations

Polymorphism in the 5′-Leader Cistron of theβ 2-Adrenergic Receptor Gene Associated with Obesity and Type 2 Diabetes

1999 • 74 citations

Beta-adrenergic receptor polymorphisms: cardiovascular disease associations and pharmacogenetics.

2002 • 72 citations

Polymorphisms of the β2-adrenoceptor (ADRB2) gene and essential hypertension: the ECTIM and PEGASE studies

2002 • 71 citations

Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families

2000 • 70 citations

Effects of beta1-adrenoceptor genetic polymorphisms on resting hemodynamics in patients undergoing diagnostic testing for ischemia

2001 • 67 citations

Association of β₂-Adrenoreceptor Variants with Bronchial Hyperresponsiveness

2000 • 64 citations

The Pharmacologic Approach to the Treatment of Obesity

1997 • 64 citations

Pharmacogenomics of blood pressure response to antihypertensive treatment

2005 • 64 citations

Association of β3-adrenoceptor polymorphism with obesity and diabetes: current status

1997 • 62 citations

Molecular cloning of a human β3‐adrenergic receptor cDNA

1993 • 61 citations

beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease.

2002 • 61 citations

Polymorphisms of the β₂‐adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men

2000 • 59 citations

Future Research Directions in Asthma

2004 • 59 citations

The Arg389Gly ??1-adrenoceptor gene polymorphism determines contractile response to catecholamines

2004 • 58 citations

The CAREGENE study: polymorphisms of the β1-adrenoceptor gene and aerobic power in coronary artery disease

2006 • 55 citations

β 2 -Adrenergic Receptor Polymorphisms and Haplotypes Are Associated With Airways Hyperresponsiveness Among Nonsmoking Men

2004 • 53 citations

Interaction between cardiac sympathetic drive and heart rate in heart failure

2004 • 48 citations

The Emerging Pharmacogenomics of the β‐Adrenergic Receptors

2004 • 48 citations

β₂ adrenergic receptor 5′ haplotypes influence promoter activity

2002 • 46 citations

Regulation of beta₃‐adrenoceptor expression in white fat cells*

1995 • 46 citations

Functional responses of human ??1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms

2004 • 42 citations

Human β-adrenergic receptor gene haplotypes and venodilation in vivo

2005 • 40 citations

Pancreatic beta-cells expressing the Arg64 variant of the beta(3)-adrenergic receptor exhibit abnormal insulin secretory activity

2001 • 38 citations

Trp64Arg Mutation of ?-Adrenergic Receptor in Essential Hypertension Insulin Resistance and the Adrenergic System

1997 • 37 citations

Association of Trp64Arg β3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population

1999 • 34 citations

The negative inotropic action of catecholamines: Role of β<SUB>3</SUB>-adrenoceptors

2000 • 30 citations

Haplotype Analysis of the β2 Adrenergic Receptor Gene and Risk of Myocardial Infarction in Humans

2004 • 29 citations

Insulin Resistance and Type 2 Diabetes Mellitus

1999 • 27 citations

Association of β2 adrenergic receptor polymorphisms and related haplotypes with triglyceride and LDL-cholesterol levels

2005 • 26 citations

Differential Desensitization of Homozygous Haplotypes of the β₂-Adrenergic Receptor in Lymphocytes

2005 • 26 citations

Variability in β-adrenergic receptor response in the vasculature: Role of receptor polymorphism

2002 • 25 citations

β3‐adrenoreceptor gene polymorphism and leptin. Lack of relationship in type 2 diabetic patients

1998 • 25 citations

The negative inotropic action of catecholamines: Role of β₃-adrenoceptors

2000 • 22 citations

Pharmacogenomics of heart failure - focus on drug disposition and action*1

2004 • 20 citations

Association of β3-adrenoceptor polymorphism with obesity and diabetes: current status

1997 • 16 citations

Pharmacogenetics and Response to β-adrenergic Receptor Antagonists in Heart Failure*

2005 • 13 citations

Trp⁶⁴Arg polymorphism of the β₃-adrenergic receptor gene, pre-pregnancy obesity and risk of pre-eclampsia

2005 • 6 citations

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