The Expanding Spectrum of G Protein Diseases

Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome

1991 • 1,601 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

The Many Faces of G Protein Signaling

1998 • 1,137 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

G PROTEIN MECHANISMS: Insights from Structural Analysis

1997 • 1,061 citations

Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

1993 • 1,038 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Association of a human G-protein β3 subunit variant with hypertension

1998 • 732 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

Transgenic Gαq overexpression induces cardiac contractile failure in mice

1997 • 636 citations

Defective platelet activation in Gαq-deficient mice

1997 • 566 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

How receptors talk to trimeric G proteins

1997 • 562 citations

Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas

1987 • 519 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

1995 • 416 citations

Variable and tissue-specific hormone resistance in heterotrimeric G _s protein α-subunit (G _s α) knockout mice is due to tissue-specific imprinting of the G _s α gene

1998 • 406 citations

Stimulation of Intestinal Adenyl Cyclase by Cholera Toxin

1971 • 388 citations

Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein Gs

1993 • 344 citations

Vascular System Defects and Impaired Cell Chemokinesis as a Result of Gα ₁₃ Deficiency

1997 • 340 citations

Imprinting in Albright's hereditary osteodystrophy.

1993 • 306 citations

The McCune‐Albright syndrome: a lethal gene surviving by mosaicism

1986 • 295 citations

Rapid GDP release from Gsα in patients with gain and loss of endocrine function

1994 • 288 citations

Defect of Receptor–Cyclase Coupling Protein in Pseudohypoparathyroidism

1980 • 270 citations

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq

1997 • 259 citations

Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism

1980 • 240 citations

Embryonic cardiomyocyte hypoplasia and craniofacial defects in Galpha q/Galpha 11-mutant mice

1998 • 238 citations

AB5 toxins

1995 • 236 citations

Multiple neurological abnormalities in mice deficient in the G protein G _o

1998 • 221 citations

G Protein-Coupled Receptor Systems Involved in Cell Growth and Oncogenesis

1995 • 196 citations

G-protein diseases furnish a model for the turn-on switch

1998 • 192 citations

The gene responsible for pseudohypoparathyroidism type Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3

1998 • 190 citations

Missense mutation in the gene encoding the α subunit of rod transducin in the Nougaret form of congenital stationary night blindness

1996 • 185 citations

Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension.

1995 • 184 citations

Gα _o is necessary for muscarinic regulation of Ca ²⁺ channels in mouse heart

1997 • 148 citations

Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice.

1994 • 119 citations

Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity.

1981 • 97 citations

A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.

1994 • 84 citations

GENOMIC IMPRINTING: Nature and Clinical Relevance

1997 • 70 citations

Pseudohypoparathyroidism, a Novel Mutation in the βγ-Contact Region of Gsα Impairs Receptor Stimulation

1996 • 69 citations

The Molecular Basis of Disorders Caused by Defects in G Proteins

1997 • 68 citations

Conditional activation defect of a human G _sα mutant

1997 • 59 citations

Multiple Abnormalities of Anterior Pituitary Hormone Secretion in Association with Pseudohypoparathyroidism*

1980 • 39 citations

Mechanistic and Developmental Aspects of Genetic Imprinting in Mammals

1995 • 37 citations

Pseudohypoparathyroidism: mutation affecting adenylate cyclase.

1982 • 21 citations