The Myocardium-protective Gly-49 Variant of the β1-Adrenergic Receptor Exhibits Constitutive Activity and Increased Desensitization and Down-regulation

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

1993 • 1,213 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

β-Adrenergic Receptor Blockade in Chronic Heart Failure

2000 • 1,020 citations

Adrenergic effects on the biology of the adult mammalian cardiocyte.

1992 • 873 citations

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

2000 • 869 citations

Progressive hypertrophy and heart failure in β ₁ -adrenergic receptor transgenic mice

1999 • 769 citations

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

1993 • 769 citations

A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor

1999 • 588 citations

Opposing Effects of β ₁ - and β ₂ -Adrenergic Receptors on Cardiac Myocyte Apoptosis

1999 • 557 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac G _sα Overexpression

1996 • 266 citations

Myocardial-Directed Overexpression of the Human β1-Adrenergic Receptor in Transgenic Mice

2000 • 264 citations

Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosphate-Ca2+ cascades.

1995 • 234 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

A novel polymorphism in the gene coding for the beta1-adrenergic receptor associated with survival in patients with heart failure

2000 • 211 citations

Mutation of a Highly Conserved Aspartic Acid in the β₂Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6

1999 • 203 citations

The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization.

1993 • 173 citations

Mutation of Asn111 in the Third Transmembrane Domain of the AT1A Angiotensin II Receptor Induces Its Constitutive Activation

1997 • 155 citations

Structure-based conformational preferences of amino acids

1999 • 143 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Characterization of a Unique Genetic Variant in the β1-adrenoceptor Gene and Evaluation of its Role in Idiopathic Dilated Cardiomyopathy

1999 • 109 citations

Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.

1992 • 106 citations

Interaction with β-Arrestin Determines the Difference in Internalization Behavior between β1- and β2-Adrenergic Receptors

2000 • 92 citations

Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice.

2001 • 90 citations

β2-Adrenergic Receptor Down-regulation

1999 • 88 citations

Constitutively ActiveAlpha-1b Adrenergic Receptor Mutants Display Different Phosphorylation and Internalization Features

1999 • 73 citations

Constitutively active mutants of the β1‐adrenergic receptor

1999 • 46 citations

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