Amino-Terminal Polymorphisms of the Human .beta.2-Adrenergic Receptor Impart Distinct Agonist-Promoted Regulatory Properties

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

1987 • 687 citations

Mutations in the Gene Encoding for the β₂-adrenergic Receptor in Normal and Asthmatic Subjects

1993 • 633 citations

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.

1993 • 470 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Structural features required for ligand binding to the beta-adrenergic receptor.

1987 • 358 citations

Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor

1989 • 271 citations

From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors

1992 • 143 citations

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

1991 • 136 citations

Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.

1992 • 129 citations

Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs.

1992 • 117 citations

Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.

1990 • 109 citations

Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.

1992 • 106 citations

β₂- and α₂-Adrenergic Receptors and Receptor Coupling to Adenylate Cyclase in Human Mononuclear Leukocytes and Platelets in Relation to Physiological Variations of Sex Steroids*

1984 • 42 citations

Mutation of tyrosine-350 impairs the coupling of the .beta.2-adrenergic receptor to the stimulatory guanine nucleotide binding protein without interfering with receptor down-regulation

1993 • 15 citations

Quantitative Comparison of Bromoacetylated Derivatives of Alprenolol and Pindolol on Beta-Adrenergic Receptor Binding and Mobility in S49 Cells

1989 • 1 citations