The Human Immunodeficiency Virus Type 1 NEF Protein Binds the Src-Related Tyrosine Kinase Lck SH2 Domain Through a Novel Phosphotyrosine Independent Mechanism

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Protein modules and signalling networks

1995 • 2,447 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1996 • 1,041 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1987 • 523 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1996 • 460 citations

Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain

1996 • 433 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

1995 • 385 citations

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

1991 • 375 citations

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene

1994 • 372 citations

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

1994 • 305 citations

p62, a Phosphotyrosine-independent Ligand of the SH2 Domain of p56 , Belongs to a New Class of Ubiquitin-binding Proteins

1996 • 289 citations

HIV accessory proteins: Leading roles for the supporting cast

1995 • 283 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

1995 • 256 citations

Identification of a nef allele that causes lymphocyte activation and acute disease in Macaque monkeys

1995 • 252 citations

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

1993 • 241 citations

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-$gamma;1 complexed with a high affinity binding peptide

1994 • 239 citations

Human immunodeficiency virus type 1 Nef associateswith a cellular serine kinase in T lymphocytes.

1994 • 227 citations

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

1997 • 208 citations

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1997 • 206 citations

SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

1997 • 201 citations

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

1994 • 195 citations

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1991 • 192 citations

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef

1995 • 191 citations

Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

1994 • 176 citations

Three-dimensional solution structure of the src homology 2 domain of c-abl

1992 • 174 citations

Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase

1992 • 166 citations

Physical and Functional Interaction of Nef with Lck

1996 • 165 citations

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

1997 • 156 citations

Nonclassical binding of formylated peptide in crystal structure of the MHC class lb molecule H2-M3

1995 • 155 citations

Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family

1996 • 154 citations

LEUKOCYTE PROTEIN TYROSINE KINASES:Potential Targets for Drug Discovery

1997 • 144 citations

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

1996 • 142 citations

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1996 • 134 citations

Cytoplasmic localization of the HTLV-III 3′orf protein in cultured T cells

1986 • 134 citations

Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines

1995 • 128 citations

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.

1993 • 117 citations

Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice

1996 • 108 citations

Phosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal region.

1995 • 107 citations

The HIV Nef Protein Associates with Protein Kinase C Theta

1996 • 100 citations

Multiple kinases mediate T-cell-receptor signalling

1995 • 96 citations

Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner

1994 • 95 citations

HIV-1 Nef Association with Cellular Serine Kinase Correlates with Enhanced Virion Infectivity and Efficient Proviral DNA Synthesis

1996 • 94 citations

SH2 Domain Function Is Essential for the Role of the Lck Tyrosine Kinase in T Cell Receptor Signal Transduction

1996 • 92 citations

Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains.

1994 • 92 citations

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

1993 • 87 citations

Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene.

1994 • 84 citations

Identification of Lck-binding Elements in Tip of Herpesvirus Saimiri

1995 • 84 citations

A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction.

1992 • 78 citations

Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri

1995 • 78 citations

Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 Nef gene-induced expression.

1996 • 76 citations

The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix

1997 • 69 citations

In Vivo Association of v-Abl with Shc Mediated by a Non-phosphotyrosine-dependent SH2 Interaction

1996 • 65 citations

Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.

1994 • 64 citations

Activation of the T-cell receptor signaling pathway by Nef from an aggressive strain of simian immunodeficiency virus

1997 • 58 citations

Demonstration of a Direct Interaction between p56 and the Cytoplasmic Domain of CD45 in Vitro

1996 • 57 citations

In vitro binding and phosphorylation of human immunodeficiency virus type 1 Nef protein by serine/threonine protein kinase

1995 • 48 citations

Human Immunodeficiency Virus Type I Nef Independently Affects Virion Incorporation of Major Histocompatibility Complex Class I Molecules and Virus Infectivity

1997 • 48 citations

Protein Kinase C-mediated Phosphorylation of HIV-I Nef in Human Cell Lines

1997 • 46 citations

A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand

1994 • 45 citations

Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice

1997 • 41 citations

Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetate

1997 • 33 citations

The human immunodeficiency virus type 1 Nef protein functions as a protein kinase C substrate in vitro

1995 • 25 citations

Non-receptor protein tyrosine kinases as immune targets of viruses

1997 • 25 citations

HIV-1: Is Nef a PAK animal?

1996 • 23 citations

Immunodeficiencies caused by genetic defects in protein kinases

1996 • 20 citations

DNA Tumor Viruses and Src Family Tyrosine Kinases, an Intimate Relationship

1997 • 17 citations

Deleted Work

1955 • 0 citations