CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

How Does HIV Cause AIDS?

1993 • 668 citations

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1992 • 553 citations

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1987 • 523 citations

Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.

1981 • 419 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Human CD2 3′-flanking sequences confer high-level, T cell-specific, position-independent gene expression in transgenic mice

1989 • 385 citations

HIV induces thymus depletion in vivo

1993 • 384 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Nef Protein of HIV-1 Is a Transcriptional Repressor of HIV-1 LTR

1988 • 366 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses.

1988 • 351 citations

Changes in the Human Thymus During Aging

1986 • 341 citations

The SCID-hu mouse as a model for HIV-1 infection

1993 • 288 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.

1989 • 266 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues

1983 • 245 citations

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

1990 • 228 citations

Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor.

1989 • 227 citations

Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: Mechanism for persistence in AIDS

1988 • 223 citations

Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophages

1990 • 221 citations

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1991 • 192 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

Molecular biology of the human immunodeficiency virus type 1

1991 • 174 citations

Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes

1992 • 158 citations

Correlation between cell killing and massive second-round superinfection by members of some subgroups of avian leukosis virus

1980 • 158 citations

Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme.

1991 • 155 citations

The structure of the human CD2 gene and its expression in transgenic mice.

1988 • 150 citations

Frequent and Early In Utero HIV-1 Infection

1991 • 142 citations

Cytoplasmic localization of the HTLV-III 3′orf protein in cultured T cells

1986 • 134 citations

An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor

1991 • 129 citations

Evidence for susceptibility of intrathymic T-cell precursors and their progeny carrying T-cell antigen receptor phenotypes TCR alpha beta + and TCR gamma delta + to human immunodeficiency virus infection: a mechanism for CD4+ (T4) lymphocyte depletion.

1990 • 124 citations

CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.

1992 • 119 citations

The negative effect of human immunodeficiency virus type 1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4

1993 • 114 citations

Mutational analysis of the HIV nef protein

1990 • 113 citations

Selective Inactivation of Influenza C Esterase: A Probe for Detecting 9- O -Acetylated Sialic Acids

1987 • 96 citations

Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.

1983 • 74 citations

Reduced cell surface expression of processed human immunodeficiency virus type 1 envelope glycoprotein in the presence of Nef

1993 • 66 citations

Human immunodeficiency virus type 1 glycoprotein precursor retains a CD4-p56lck complex in the endoplasmic reticulum

1992 • 61 citations

Polymorphism of the 3′ open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III

1985 • 57 citations

Immunological variation and immunohistochemical localization of HIV-1 Nef demonstrated with monoclonal antibodies

1992 • 52 citations

In Vitro Studies of HIV-1 Infection in Thymic Lymphocytes: A Putative Role of the Thymus in AIDS Pathogenesis

1990 • 48 citations

Current issues in developing a strategy for dealing with the acquired immunodeficiency syndrome.

1986 • 48 citations

In vitro studies of HIV-1 expression in thymocytes from infants and children

1992 • 46 citations

Expression and function of CD2 during murine thymocyt

1989 • 36 citations

Murine CD2 gene expression during fetal thymus ontogeny

1988 • 35 citations

Functional competency of T cell antigen receptors in human thymus.

1987 • 33 citations

High level of surface CD4 prevents stable human immunodeficiency virus infection of T-cell transfectants

1992 • 32 citations

Activation Pathways and Human Immunodeficiency Virus Type 1 Replication Are Not Altered in CD4⁺T Cells Expressing thenefProtein

1992 • 31 citations

The HIV-1nefProtein Does Not Have Guanine Nucleotide Binding, GTPase, or Autophosphorylating Activities

1991 • 23 citations