HIV accessory proteins: Leading roles for the supporting cast

Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

1995 • 4,310 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1991 • 1,613 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

1992 • 553 citations

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

1994 • 536 citations

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells

1993 • 449 citations

Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes

1992 • 447 citations

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection

1995 • 411 citations

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1994 • 401 citations

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

1994 • 305 citations

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

1994 • 287 citations

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene.

1993 • 282 citations

Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions

1993 • 275 citations

Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell

1995 • 266 citations

Identification of HIV-1 vpr product and function.

1990 • 251 citations

Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes

1992 • 251 citations

Progression to AIDS in the absence of a gene for vpr or vpx

1995 • 243 citations

Human immunodeficiency virus type 1 Nef associateswith a cellular serine kinase in T lymphocytes.

1994 • 227 citations

Human immunodeficiency virus type 1 Vpu protein is an oligomeric type I integral membrane protein

1993 • 218 citations

Induction of cell differentiation by human immunodeficiency virus 1 vpr

1993 • 214 citations

Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments

1994 • 201 citations

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA.

1991 • 192 citations

Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses.

1993 • 189 citations

The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation

1995 • 188 citations

Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency

1995 • 172 citations

Human immunodeficiency virus type 1 Vif- mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity

1995 • 138 citations

Human immunodeficiency virus type 1 Nef protein inhibits NF-kappa B induction in human T cells

1992 • 123 citations

Role of vif during Packing of the Core of HIV-1

1994 • 110 citations

Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein

1994 • 74 citations