Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.

A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures

1961 • 5,561 citations

Reduction of Ribonucleotides

1979 • 1,170 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

1979 • 577 citations

Thymidylate synthetase - a target enzyme in cancer chemotherapy

1977 • 514 citations

Eucaryotic DNA: Organization of the genome for replication

1978 • 476 citations

Tables for estimating sedimentation through linear concentration gradients of sucrose solution

1967 • 445 citations

STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI

1954 • 406 citations

Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino)methanesulfon-m-anisidide and adriamycin

1981 • 382 citations

Multienzyme complex for metabolic channeling in mammalian DNA replication.

1980 • 349 citations

Synchronization of HeLa cell cultures by inhibition of DNA polymerase a with aphidicolin

1980 • 291 citations

A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts

1979 • 272 citations

Fluorinated Pyrimidines

1965 • 252 citations

DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.

1983 • 223 citations

The pharmacology of the fluoropyrimidines.

1981 • 189 citations

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation.

1979 • 165 citations

DNA strand breaks, repair, and survival in x-irradiated mammalian cells.

1976 • 149 citations

DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells.

1982 • 100 citations

Coupled ribonucleoside diphosphate reduction, channeling, and incorporation into DNA of mammalian cells.

1982 • 100 citations

ON THE NATURE OF THYMINELESS DEATH

1971 • 94 citations

Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells.

1983 • 90 citations

Protein-associated deoxyribonucleic acid strand breaks produced in mouse leukemia L1210 cells by ellipticine and 2-methyl-9-hydroxyellipticinium

1982 • 90 citations

Perspectives on the design and biochemical pharmacology of inhibitors of thymidylate synthetase

1980 • 79 citations

Relations between synthesis of deoxyribonucleotides and DNA replication in 3T6 fibroblasts.

1985 • 71 citations

An improved method for the quantitative determination of deoxyribonucleoside triphosphates in cell extracts

1984 • 69 citations

Rapid changes in deoxynucleoside triphosphate pools in mammalian cells treated with mutagens

1983 • 68 citations

Chromosome breakage induced by thymidylate stress in thymidylate synthase-negative mutants of mouse FM3A cells.

1984 • 68 citations

Deoxyribonucleotide pools, base pairing, and sequence configuration affecting bromodeoxyuridine- and 2-aminopurine-induced mutagenesis.

1980 • 67 citations

Selection of mammalian thymidine auxotrophic cell mutants defective in thymidylate synthase by their reduced sensitivity to methotrexate

1981 • 58 citations

Single-step selection of mouse FM3A cell mutants defective in thymidylate synthetase

1980 • 42 citations

Deoxyuridine residues in DNA of thymine-requiring Bacillus subtilis strains with defective N-glycosidase activity for uracil-containing DNA

1978 • 37 citations

Mutagen-induced changes in cellular deoxycytidine triphosphate and thymidine triphosphate in Chinese hamster ovary cells

1983 • 29 citations

Metabolism and mechanism of action of 5-fluorodeoxycytidine.

1982 • 24 citations

Deoxyribonucleic acid replication in human diploid fibroblasts stimulated to proliferate.

1977 • 22 citations