Endothelial Cell Thrombin Receptors and PAR-2

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

1996 • 1,329 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

Infiltrates of Activated Mast Cells at the Site of Coronary Atheromatous Erosion or Rupture in Myocardial Infarction

1995 • 620 citations

Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

1997 • 592 citations

Role of the thrombin receptor in development and evidence for a second receptor

1996 • 506 citations

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1996 • 457 citations

Accumulation of activated mast cells in the shoulder region of human coronary atheroma, the predilection site of atheromatous rupture.

1994 • 445 citations

The Proteinase-activated Receptor 2 Is Induced by Inflammatory Mediators in Human Endothelial Cells

1996 • 352 citations

Molecular Cloning and Functional Expression of the Gene Encoding the Human Proteinase‐Activated Receptor 2

1995 • 334 citations

Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.

1992 • 308 citations

Internalization and recycling of activated thrombin receptors

1993 • 271 citations

Cylooxygenase-dependent Formation of the Isoprostane, 8-Epi Prostaglandin F2α

1995 • 262 citations

Mechanisms of Desensitization and Resensitization of Proteinase-activated Receptor-2

1996 • 246 citations

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.

1994 • 228 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

Ligand Cross-reactivity within the Protease-activated Receptor Family

1996 • 210 citations

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

1994 • 210 citations

The Mouse Proteinase-activated Receptor-2 cDNA and Gene

1995 • 187 citations

Thrombin enhances the release of endothelin from cultured porcine aortic endothelial cells

1989 • 185 citations

The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial cells.

1996 • 183 citations

Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes.

1995 • 180 citations

Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH₂, in rat vascular and gastric smooth muscle

1995 • 166 citations

Biological Consequences of Thrombin Receptor Deficiency in Mice

1996 • 163 citations

Proteolysis of the Human Platelet and Endothelial Cell Thrombin Receptor by Neutrophil-derived Cathepsin G

1995 • 149 citations

Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling.

1994 • 145 citations

Thrombin receptor activating peptides induce Ca²⁺ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet‐derived growth factor mRNA expression in cultured endothelium

1993 • 114 citations

Evidence for the Presence of a Proteinase-Activated Receptor Distinct From the Thrombin Receptor in Vascular Endothelial Cells

1996 • 109 citations

Thrombin Receptors on Human Platelets

1997 • 109 citations

Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.

1992 • 107 citations

Regulation of Thrombin Receptors on Human Umbilical Vein Endothelial Cells

1995 • 100 citations

Vascular endothelial cell activation and permeability responses to thrombin

1995 • 98 citations

Proteinase-activated receptor-2 in rat aorta: structural requirements for agonist activity of receptor-activating peptides.

1996 • 94 citations

Vascular actions of thrombin receptor peptide

1992 • 91 citations

Methods for the analysis of inositol phosphates

1989 • 89 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Inositol phosphate production and Ca2+ mobilization in human umbilical-vein endothelial cells stimulated by thrombin and histamine

1988 • 66 citations

Post-translational and Activation-dependent Modifications of the G Protein-coupled Thrombin Receptor

1995 • 63 citations

Plasmin-platelet interaction involves cleavage of functional thrombin receptor

1996 • 62 citations

Distinct Mechanisms Regulate 5-HT2 and Thrombin Receptor Desensitization

1995 • 58 citations

Immunologic analysis of the cloned platelet thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and insertion of the tethered ligand into a protected environment

1993 • 52 citations

Protease activated receptors modulate aortic vascular tone

1996 • 45 citations

Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism.

1992 • 44 citations

Bradykinin and thrombin effects on polyphosphoinositide hydrolysis and prostacyclin production in endothelial cells

1989 • 39 citations

The functional thrombin receptor is associated with the plasmalemma and a large endosomal network in cultured human umbilical vein endothelial cells

1995 • 36 citations

GTP_γS Increases Thrombin-mediated Inositol Trisphosphate Accumulation in Permeabilized Human Endothelial Cells

1989 • 34 citations

Absence of a prothrombotic state in restenotic patients?

1994 • 8 citations

Trafficking thrombin receptors

1995 • 5 citations