Biological Consequences of Thrombin Receptor Deficiency in Mice

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

Role of the thrombin receptor in development and evidence for a second receptor

1996 • 506 citations

Thrombin receptor expression in normal and atherosclerotic human arteries.

1992 • 318 citations

The measurement of thrombin in clotting blood by radioimmunoassay.

1976 • 235 citations

Ligand Cross-reactivity within the Protease-activated Receptor Family

1996 • 210 citations

Expression of Monocyte Chemotactic Protein-1 (Mcp-1) by Monocytes and Endothelial Cells Exposed to Thrombin

1993 • 209 citations

Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes.

1995 • 180 citations

Detection of functional receptors for the proteinase-activated-receptor-2-activating polypeptide, SLIGRL-NH₂, in rat vascular and gastric smooth muscle

1995 • 166 citations

Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin.

1991 • 137 citations

Characterization of thrombin receptor expression during vascular lesion formation.

1994 • 136 citations

Thrombin receptor activating peptides induce Ca²⁺ mobilization, barrier dysfunction, prostaglandin synthesis, and platelet‐derived growth factor mRNA expression in cultured endothelium

1993 • 114 citations

Agonist Recognition by Proteinase-activated Receptor 2 and Thrombin Receptor

1996 • 107 citations

A novel biologic activity of thrombin: stimulation of monocyte chemotactic protein production.

1994 • 102 citations

Species Variability in Platelet and other Cellular Responsiveness to Thrombin Receptor-derived Peptides

1994 • 99 citations

Vascular actions of thrombin receptor peptide

1992 • 91 citations

A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells

1991 • 90 citations

Evaluation of electrical aggregometry: comparison with optical aggregometry, secretion of ATP, and accumulation of radiolabeled platelets.

1983 • 89 citations

Thrombin-Elicited Contractile Responses of Aortic Smooth Muscle

1985 • 86 citations

Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.

1994 • 82 citations

Solid tumor cells express functional "tethered ligand" thrombin receptor.

1995 • 79 citations

Thrombin receptor peptide inhibits thrombin-induced increase in endothelial permeability by receptor desensitization.

1993 • 75 citations

Thrombin Receptor Structure and Function

1993 • 73 citations

Glycoprotein Ib (GPIb)-dependent and GPIb-independent pathways of thrombin-induced platelet activation

1991 • 72 citations

Species differences in platelet responses to thrombin and SFLLRN. Receptor-mediated calcium mobilization and aggregation, and regulation by protein kinases

1995 • 70 citations

Presence of the seven transmembrane thrombin receptor on human tumour cells: effect of activation on tumour adhesion to platelets and tumour tyrosine phosphorylation

1996 • 69 citations

Protease Nexin-1 and Thrombin: Injury-related Processes in the Brain

1993 • 68 citations

Receptor Mechanism of Thrombin-Induced Endothelium-Dependent and Endothelium-Independent Coronary Vascular Effects in Dogs

1993 • 66 citations

Thrombin receptor 14-amino acid peptide mediates endothelial hyperadhesivity and neutrophil adhesion by P-selectin-dependent mechanism.

1992 • 44 citations

Comparison of Responses Elicited by Alpha-Thrombin in Isolated Canine Basilar, Coronary, Mesenteric, and Renal Arteries

1984 • 43 citations

Involvement of the "tethered ligand" receptor in thrombin-induced endothelium-mediated relaxations

1993 • 39 citations

Analysis of thrombin generation in plasma

1994 • 34 citations

Cardiovascular actions of thrombin receptor activation in vivo.

1996 • 18 citations

Effect of Thrombin on Isolated Canine Blood Vessels

1982 • 16 citations

Unmasking of thrombin vasoconstriction in isolated perfused dog hearts after intracoronary infusion of air embolus.

1987 • 10 citations

Activation of vascular thrombin receptors mediates cardiac response to alpha-thrombin in isolated, perfused guinea pig heart

1996 • 8 citations