Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

1985 • 968 citations

Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

1987 • 736 citations

Knowledge-based prediction of protein structures and the design of novel molecules

1987 • 653 citations

Domains specifying thrombin–receptor interaction

1991 • 553 citations

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca²⁺ mobilization

1991 • 464 citations

Identification of structural motifs from protein coordinate data: Secondary structure and first‐level supersecondary structure*

1988 • 409 citations

Oncogenes, Growth Factors, and Signal Transduction

1989 • 296 citations

Comparative model-building of the mammalian serine proteases

1981 • 286 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Statistical and energetic analysis of side‐chain conformations in oligopeptides

1983 • 238 citations

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.

1990 • 237 citations

The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity.

1991 • 229 citations

Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.

1992 • 178 citations

Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.

1988 • 137 citations

“Thrombin” receptor-directed ligand accounts for activation by thrombin of platelet phospholipase C and accumulation of 3-phosphorylated phosphoinositides.

1991 • 119 citations

Design of bioactive peptides based on antibody hypervariable region structures. Development of conformationally constrained and dimeric peptides with enhanced affinity.

1991 • 110 citations

Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.

1992 • 107 citations

A 14 amino acid peptide derived from the amino terminus of the cleaved thrombin receptor elevates intracellular calcium and stimulates prostacyclin production in human endothelial cells

1991 • 90 citations

Monoclonal antibodies : applications in clinical oncology

1991 • 69 citations

The Role of GTP-Binding Proteins in Platelet Activation

1991 • 53 citations

Contact residues and predicted structure of the reovirus type 3-receptor interaction

1991 • 39 citations

Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties

1992 • 31 citations