Trafficking thrombin receptors

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

cDNA cloning and expression of a hamster α‐thrombin receptor coupled to Ca²⁺ mobilization

1991 • 464 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Internalization and recycling of activated thrombin receptors

1993 • 271 citations

The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.

1992 • 248 citations

Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.

1994 • 228 citations

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.

1994 • 218 citations

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

1994 • 210 citations

Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling

1993 • 205 citations

Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus.

1992 • 190 citations

Differential activation of p44mapk (ERK1) by α-thrombin and thrombin-receptor peptide agonist

1993 • 163 citations

Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling.

1994 • 145 citations

Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.

1988 • 137 citations

Receptor and G protein-mediated responses to thrombin in HEL cells.

1991 • 109 citations

Homologous desensitization of HEL cell thrombin receptors. Distinguishable roles for proteolysis and phosphorylation.

1992 • 107 citations

Thrombin receptor function and cardiovascular disease

1994 • 102 citations

Regulation of Thrombin Receptors on Human Umbilical Vein Endothelial Cells

1995 • 100 citations

The thrombin receptor extracellular domain contains sites crucial for peptide ligand-induced activation.

1993 • 95 citations

Ni-mediated inhibition of human platelet adenylate cyclase by thrombin

1984 • 94 citations

Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets

1993 • 80 citations

Thrombin‐induced prostacyclin biosynthesis in human endothelium: Role of guanine nucleotide regulatory proteins in stimulus/coupling responses

1990 • 53 citations

Immunologic analysis of the cloned platelet thrombin receptor activation mechanism: evidence supporting receptor cleavage, release of the N-terminal peptide, and insertion of the tethered ligand into a protected environment

1993 • 52 citations

Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function.

1986 • 46 citations

Thrombin receptor 14-amino acid peptide binds to endothelial cells and stimulates calcium transients

1992 • 42 citations

The functional thrombin receptor is associated with the plasmalemma and a large endosomal network in cultured human umbilical vein endothelial cells

1995 • 36 citations

GTP_γS Increases Thrombin-mediated Inositol Trisphosphate Accumulation in Permeabilized Human Endothelial Cells

1989 • 34 citations

Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation.

1993 • 32 citations

Differences in intracellular calcium signaling after activation of the thrombin receptor by thrombin and agonist peptide in osteoblast-like cells.

1994 • 31 citations

Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties

1992 • 31 citations

Distinct receptors and signaling pathways in alpha-thrombin- and thrombin receptor peptide-induced vascular contractions.

1994 • 30 citations

Molecular mechanisms of homologous desensitization and internalization of muscarinic receptors in primary cultures of neonatal corticostriatal neurons.

1990 • 26 citations