Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.

A stereotaxic atlas of the rat brain

1967 • 4,710 citations

Neurobiological Similarities in Depression and Drug Dependence: A Self-Medication Hypothesis

1998 • 752 citations

Dramatic decreases in brain reward function during nicotine withdrawal

1998 • 676 citations

Dynamics of Drug Dependence

1973 • 608 citations

Molecular and Cellular Aspects of Nicotine Abuse

1996 • 605 citations

Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment

1992 • 540 citations

Postcocaine anhedonia. An animal model of cocaine withdrawal.

1991 • 505 citations

Symptoms of Tobacco Withdrawal

1991 • 449 citations

The paradox of nicotinic acetylcholine receptor upregulation by nicotine

1990 • 350 citations

Decreased brain reward produced by ethanol withdrawal.

1995 • 349 citations

Rodent model of nicotine abstinence syndrome

1992 • 326 citations

Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal

1990 • 317 citations

Euphorigenic drugs: effects on the reward pathways of the brain.

1979 • 299 citations

Pharmacokinetics of Naloxone in Rats and in Man

1976 • 284 citations

Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis.

1994 • 275 citations

Amphetamine and the reward system: Evidence for tolerance and post-drug depression

1976 • 203 citations

Can induced moods trigger drug-related responses in opiate abuse patients?

1994 • 180 citations

Rewarding brain stimulation: Role of tegmental cholinergic neurons that activate dopamine neurons.

1993 • 179 citations

Multiple Determinants of Dihydro‐β‐Erythroidine Sensitivity on Rat Neuronal Nicotinic Receptor α Subunits

1996 • 173 citations

The nicotinic antagonist mecamylamine precipitates nicotine abstinence syndrome in the rat

1994 • 168 citations

Naloxone precipitates nicotine abstinence syndrome in the rat

1993 • 147 citations

Behavioral manifestations of the nicotine abstinence syndrome in the rat: peripheral versus central mechanisms

1997 • 121 citations

Aversive properties of opiate receptor blockade: evidence for exclusively central mediation in naive and morphine-dependent rats

1988 • 117 citations

Endogenous κ-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release

1994 • 110 citations

Effects of nicotine on the threshold for rewarding brain stimulation in rats

1992 • 107 citations

Behavioral and Biochemical Manifestations of Mecamylamine-Precipitated Nicotine Withdrawal in the Rat Role of Nicotinic Receptors in the Ventral Tegmental Area

1999 • 102 citations

Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat - interactions between the two drugs

1999 • 96 citations

What is the nature of mecamylamine's antagonism of the central effects of nicotine?

1989 • 92 citations

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization.

1998 • 77 citations

The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion

1994 • 68 citations

Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion‐blocking drug chlorisondamine

1984 • 62 citations

Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (+/-)-epibatidine in rats.

1998 • 58 citations

Nicotine Abstinence Syndrome Precipitated by the Competitive Nicotinic Antagonist Dihydro-β-Erythroidine

1998 • 50 citations

Nicotine Abstinence Syndrome Precipitated by Central But Not Peripheral Hexamethonium

1997 • 43 citations

Clonidine Blocks Acquisition But not Expression of Conditioned Opiate Withdrawal in Rats

1998 • 38 citations

Uptake and distribution of some quaternary ammonium compounds in the central nervous system of the rat.

1969 • 20 citations

Persistent nicotinic blockade by chlorisondamine of noradrenergic neurons in rat brain and cultured PC12 cells

1998 • 20 citations

Intraneuronal accumulation and persistence of radiolabel in rat brain following in vivo administration of [³H]‐chlorisondamine

1995 • 15 citations