MECHANISMS FOR THE CONTROL OF GENE ACTIVITY DURING DEVELOPMENT

The chemical basis of morphogenesis

1952 • 11,233 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

CpG-rich islands and the function of DNA methylation

1986 • 3,760 citations

CpG Islands in vertebrate genomes

1987 • 3,315 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

Positional information and the spatial pattern of cellular differentiation

1969 • 2,957 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

Nucleic acid junctions and lattices

1982 • 2,290 citations

DNA methylation and epigenetic inheritance

1990 • 2,198 citations

DNA Modification Mechanisms and Gene Activity During Development

1975 • 1,859 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Gene Activity in Early Development

1968 • 1,725 citations

X inactivation, differentiation, and DNA methylation

1975 • 1,283 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development

1987 • 1,088 citations

The Inheritance of Epigenetic Defects

1987 • 1,058 citations

The Developmental Capacity of Nuclei taken from Intestinal Epithelium Cells of Feeding Tadpoles

1962 • 1,020 citations

A gradient of bicoid protein in Drosophila embryos

1988 • 1,015 citations

DNA methylation and gene activity

1988 • 904 citations

Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells

1988 • 891 citations

The variation of animals and plants under domestication /

1883 • 849 citations

The 5-methylcytosine content of DNA from human tumors

1983 • 835 citations

STRUCTURE OF RIBOSOMAL RNA

1984 • 793 citations

Positional Information in Chick Limb Morphogenesis

1973 • 718 citations

ALTERNATIVE SPLICING: A UBIQUITOUS MECHANISM FOR THE GENERATION OF MULTIPLE PROTEIN ISOFORMS FROM SINGLE GENES

1987 • 712 citations

Differential activity of maternally and paternally derived chromosome regions in mice

1985 • 708 citations

ALTERNATIVE SPLICING IN THE CONTROL OF GENE EXPRESSION

1989 • 701 citations

Determination of Anteroposterior Polarity in Drosophila

1987 • 651 citations

DNA Methylation Decreases in Aging But Not in Immortal Cells

1983 • 635 citations

MAMMALIAN X-CHROMOSOME INACTIVATION

1983 • 635 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter.

1988 • 587 citations

Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans

1980 • 567 citations

Assembly and propagation of repressed and derepressed chromosomal states

1985 • 518 citations

Inheritance of DNA methylation in Coprinus cinereus.

1986 • 512 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

Genomic 5-methyldeoxycytidine decreases with age.

1987 • 504 citations

A molecular gradient in early Drosophila embryos and its role in specifying the body pattern

1986 • 504 citations

On the nature of hereditable variation in cultured somatic cells

1976 • 497 citations

Sex in flies: the splice of life

1989 • 468 citations

Embryonic Development and Induction

1938 • 459 citations

Clonal analysis of oligodendrocyte development in culture: Evidence for a developmental clock that counts cell divisions

1986 • 456 citations

DIFFERENTIAL IMPRINTING AND EXPRESSION OF MATERNAL AND PATERNAL GENOMES

1988 • 451 citations

CELLULAR LOCALIZATION OF IMMUNOGLOBULINS WITH DIFFERENT ALLOTYPIC SPECIFICITIES IN RABBIT LYMPHOID TISSUES

1965 • 444 citations

5-Methylcytosine, Gene Regulation, and Cancer

1983 • 425 citations

Altering gene expression with 5-azacytidine

1985 • 408 citations

Embryonic induction - molecular prospects

1987 • 381 citations

Compartments and Polyclones in Insect Development

1975 • 380 citations

Rearrangement of duplicated DNA in specialized cells of Neurospora

1987 • 366 citations

Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation

1987 • 363 citations

Genes-in-Pieces Revisited

1985 • 362 citations

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

1987 • 356 citations

Mapping of Behaviour in Drosophila Mosaics

1972 • 354 citations

Repeat-induced G-C to A-T Mutations in Neurospora

1989 • 353 citations

Information for the dorsal–ventral pattern of the Drosophila embryo is stored as maternal mRNA

1984 • 335 citations

DNA modification of a maize transposable element correlates with loss of activity.

1986 • 331 citations

Trends in Genetic Analysis

1959 • 282 citations

“Fertile” Intestine Nuclei

1966 • 280 citations

Parental exposure to X rays and chemicals induces heritable tumours and anomalies in mice.

1982 • 276 citations

DNA Methylation and Cancer

2000 • 266 citations

Cell lineage of the imaginal discs in Drosophila gynandromorphs

1969 • 263 citations

A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting.

1989 • 260 citations

Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.

1980 • 255 citations

Embryology and Phylogeny in Annelids and Arthropods.

1974 • 254 citations

The inheritance of acquired epigenetic variations

1989 • 252 citations

Lineage-specific gene expression and the regulative capacities of the sea urchin embryo: a proposed mechanism

1989 • 249 citations

Isolation of caudal , a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage

1985 • 238 citations

Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis.

1986 • 224 citations

Selective Silencing of Eukaryotic DNA

1975 • 224 citations

Principles of embryology

1956 • 223 citations

MECHANISMS OF X-CHROMOSOME REGULATION

1988 • 222 citations

Age related reactivation of an X-linked gene

1987 • 220 citations

Induction of thymidine kinase in enzyme-deficient chinese hamster cells

1982 • 205 citations

Comprehensive Virology

1979 • 202 citations

A new theory of carcinogenesis

1979 • 201 citations

Transposase activity of the Ac controlling element in maize is regulated by its degree of methylation

1986 • 193 citations

A yellow crescent cytoskeletal domain in ascidian eggs and its role in early development

1983 • 187 citations

Position effect variegation in the mouse

1974 • 184 citations

The William Allan memorial award address: X-chromosome inactivation and the location and expression of X-linked genes.

1988 • 180 citations

Lineages, quantal cell cycles, and the generation of cell diversity

1975 • 176 citations

Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection

1974 • 174 citations

Inheritance of allelic blueprints for methylation patterns

1988 • 172 citations

DEVELOPMENTAL GENETICS OF THE DROSOPHILA EGG I. IDENTIFICATION OF 59 SEX-LINKED CISTRONS WITH MATERNAL EFFECTS ON EMBRYONIC DEVELOPMENT

1977 • 164 citations

Generation of biological patterns and form: Some physical, mathematical, and logical aspects

1981 • 159 citations

Targeted transformation of Ascobolus immersus and de novo methylation of the resulting duplicated DNA sequences.

1989 • 158 citations

DNA, mutations and aging

1989 • 158 citations

Building for Earthquakes

2004 • 157 citations

Control Circuits for Determination and Transdetermination

1973 • 153 citations

Cell Culture and Somatic Variation

1964 • 147 citations

The tumorigenicity of 5-azacytidine in the male Fischer rat

1984 • 143 citations

Konstanz, Wechsel und Typus der Determination und Differenzierung in Zellen aus männlichen Genitalanlagen von Drosophila melanogaster nach Dauerkultur in vivo

1966 • 139 citations

Muscle-specific activation of a methylated chimeric actin gene

1986 • 135 citations

Genomic imprinting.

1988 • 132 citations

Epigenetics and Evolution

2014 • 131 citations

Lampbrush Chromosomes

1986 • 127 citations

Evidence that a regulatory gene autoregulates splicing of its transcript.

1987 • 123 citations

Expression of the G6PD locus on the human X chromosome is associated with demethylation of three CpG islands within 100 kb of DNA.

1988 • 119 citations

The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation

1987 • 119 citations

Message sequences and short repetitive sequences are interspersed in sea urchin egg poly(A)+ RNAs

1980 • 118 citations

Chromosome error propagation and cancer

1989 • 114 citations

Mechanism for RNA splicing of gene transcripts

1979 • 114 citations

Genomic sequencing reveals a 5-methylcytosine-free domain in active promoters and the spreading of preimposed methylation patterns.

1989 • 109 citations

Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells.

1986 • 109 citations

Transgenes as molecular probes for genomic imprinting

1988 • 108 citations

Evidence for transfer of macromolecular RNA between mammalian cells in culture

1971 • 107 citations

Models of a dual inheritance system

1990 • 107 citations

DNA Methylation and Cancer

1985 • 104 citations

Characterization of the maize transposable element Ac by internal deletions

1988 • 104 citations

Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting

1990 • 104 citations

Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts

1986 • 104 citations

Clonal analysis of determination dynamics in cultures of imaginal disks in Drosophila melanogaster

1967 • 104 citations

Methylation and the X chromosome

1986 • 103 citations

CONTROL OF ANTIGEN GENE EXPRESSION IN AFRICAN TRYPANOSOMES

1988 • 101 citations

Hypothesis on Differentiation and the Inheritance of Gene Superstructure

1973 • 99 citations

Changes in DNA methylation are associated with loss of insecticide resistance in the peach‐potato aphid Myzus persicae (Sulz.)

1989 • 97 citations

Extent of DNA methylation in human tumor cells.

1983 • 97 citations

Role of de novo DNA methylation in the glucocorticoid resistance of a T-lymphoid cell line

1983 • 95 citations

Promoters selected from random DNA sequences.

1986 • 94 citations

A Portable Signal Causing Faithful DNA Methylation de Novo in Neurospora crassa

1987 • 93 citations

Towards an understanding of position effect variegation

1989 • 90 citations

Demethylation of specific sites in the 5' region of the inactive X-linked human phosphoglycerate kinase gene correlates with the appearance of nuclease sensitivity and gene expression.

1988 • 90 citations

The transplantation of nuclei from single cultured cells into enucleate frogs’ eggs

1970 • 86 citations

Assembly of an active chromatin structure during replication

1979 • 86 citations

Effect of ageing on reactivation of the human X-linked HPRT locus

1988 • 80 citations

How does the cell count the number of ectopic copies of a gene in the premeiotic inactivation process acting in Ascobolus immersus?

1990 • 77 citations

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells.

1984 • 76 citations

Timing Mechanisms in Early Embryonic Development

1982 • 74 citations

Molecular Biology of Aging

1985 • 73 citations

The mammalian cell as a microorganism

1960 • 68 citations

Stability of the Cellular Translation Process

1984 • 67 citations

Determination of trace amounts of 5-methylcytosine in DNA by reverse-phase high-performance liquid chromatography

1987 • 66 citations

Prenatal exposure to chemical carcinogens and its effect on subsequent generations.

1979 • 64 citations

Genomic sequencing and in vivo footprinting of an expression-specific DNase I-hypersensitive site of avian vitellogenin II promoter reveal a demethylation of a mCpG and a change in specific interactions of proteins with DNA.

1988 • 62 citations

DNA Damage and Repair during Cellular Aging

1989 • 61 citations

Reactivation of the Mutator transposable element system following gamma irradiation of seed

1988 • 56 citations

Measurement of developmental time by cells of early embryos

1990 • 53 citations

Differences in methylation on the active and inactive human X chromosomes

1985 • 52 citations

Premeiotic disruption of duplicated and triplicated copies of the Neurospora crassa am (glutamate dehydrogenase) gene

1989 • 51 citations

DNA methylation and cell memory

1989 • 50 citations

Mutations, epimutations, and the developmental programming of the maize Suppressor‐mutator transposable element

1989 • 49 citations

DNA methylation of maize transposable elements is correlated with activity

1990 • 45 citations

Models for maternally supplied positional information and the activation of segmentation genes in Drosophila embryogenesis

1988 • 43 citations

High-frequency induction by 5-azacytidine of proline independence in CHO-K1 cells

1984 • 43 citations

DNA sequences of random origin as probes of Escherichia coli promoter architecture.

1988 • 41 citations

DNA methylation affecting the transforming activity of the human Ha-ras oncogene.

1987 • 41 citations

Sequence-specific methylation in a downstream region of the late E2A promoter of adenovirus type 2 DNA prevents protein binding

1989 • 39 citations

Cell-cell interactions that specify certain cell fates in C. elegans development

1989 • 39 citations

The Cell in Development and Inheritance

1897 • 37 citations

The State of DNA Modification within and Flanking Maize Transposable Elements

1988 • 37 citations

Toward a Biological Understanding of the Ageing Process

1988 • 37 citations

A conceptual ambiguity that contributed to the neglect of Mendel's paper.

1985 • 37 citations

Delta-crystallin genes become hypomethylated in postmitotic lens cells during chicken development.

1987 • 35 citations

ON THE INHERITANCE OF DIFFERENTIATED TRAITS

1974 • 35 citations

Relationships Between the Heterogeneity of Immunoglobulins and the Differentiation of Plasma Cells

1967 • 34 citations

Age-Related Changes in DNA Methylation: Do They Represent Continued Developmental Changes?

1989 • 33 citations

Mechanisms for changing gene expression and their possible relationship to carcinogenesis.

1985 • 33 citations

Age-related reactivation of an X-linked gene close to the inactivation centre in the mouse

1988 • 32 citations

Demethylation of genes in animal cells

1990 • 32 citations

Methylation and expression of the Myo D1 determination gene

1990 • 31 citations

Stem cells: a problem in asymmetry

1988 • 31 citations

Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants.

1987 • 31 citations

Variants inducible for glutamine synthetase in V79-56 cells

1984 • 29 citations

Studies on the Cytoplasmic Organization of Early Drosophila Embryos

1985 • 28 citations

Unequal parental contributions: genomic imprinting in mammals.

1989 • 28 citations

Is there a Viral Component in the Genetic Background?

1970 • 26 citations

Complexities in Gene Regulation by Promoter Methylation

1989 • 25 citations

High-frequency reactivation of X-linked genes in chinese hamster � human hybrid cells

1987 • 25 citations

The significance of DNA methylation patterns: promoter inhibition by sequence-specific methylation is one functional consequence

1990 • 24 citations

DNA methylation and specific protein—DNA interactions

1990 • 21 citations

De novo methylation as major event in the inactivation of transfected herpesvirus thymidine kinase genes in human cells

1989 • 21 citations

Tissue specific expression of avian vitellogenin gene is correlated with DNA hypomethylation and in vivo specific protein-DNA interactions

1990 • 21 citations

A long, nontranslatable poly(A) RNA stored in the egg of the sea urchin Strongylocentrotus purpuratus.

1988 • 20 citations

A Growth Curve of Cell Numbers In the Neural Retina of Embryonic Chicks

1984 • 16 citations

Inactivation and reactivation of sex-linked steroid sulfatase gene in murine cell culture

1988 • 15 citations

A mechanism for RNA–RNA splicing and a model for the control of gene expression

1979 • 15 citations

Genetic Control of Bacteriophage T4 Morphogenesis

1973 • 14 citations

DNA methylation and gene regulation

1990 • 14 citations

Molecular hypotheses for position-effect variegation: Anti-sense transcription and promoter occlusion

1988 • 14 citations

Successes and limitations of molecular biology

1988 • 14 citations

The primacy of cell interactions in development

1989 • 11 citations

A theory for developmental control by a program encoded in the genome

1986 • 11 citations

Cytosine methylation in the EcoRI site of active and inactive herpesvirus thymidine kinase promoters

1989 • 10 citations

The Molecular Basis of Positional Signalling

1990 • 9 citations

Model nerve net can produce rectilinear, non-diffuse propagation as seen in the skin plexus of sea urchins

1990 • 9 citations

Genes, Proteins and Cellular Aging

1986 • 8 citations

Chromosome Structure and Function

1972 • 7 citations

Drosophila back to front

1989 • 7 citations

Repair-modification and evolution of the eukaryotic genome organization

1989 • 6 citations

A molecular approach to the problem of positional information in eggs and early embryos.

1989 • 6 citations

The Florey Lecture, 1988 - From egg to embryo: the initiation of cell differentiation in Amphibia

1989 • 5 citations